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The development of new bioactive cement for treatments of fractures, bone defects, and artificial joints

开发用于治疗骨折、骨缺损和人工关节的新型生物活性水泥

基本信息

批准号：
16591475
负责人：
SUZUKI Masahiko
金额：
$ 2.18万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591475/
关键词：
Cement Bioactive γ-methacryloxypropyltrimethoxysilan Calcium acetate PMMA 生体活性骨欠損

项目摘要

Polymethylmethacrylate (PMMA) bone cement is widely used for prosthetic fixation in orthopaedic surgery ; however, the interface between bone and cement is a weak zone. We developed a bioactive PMMA cement through modification with γ-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. The purpose of this study was to compare the handling, mechanical and histological properties of the modified bone cement with those of the conventional cement. The modified specimens exhibited higher bonding strength between bone and implant. The push-out load of the modified PMMA bone cement reached 1.60 MPa in 3 weeks, which was maintained up to 8 weeks after implantation, while those of the conventional bone cement remained low throughout the examined periods in this study. Histological observation and micro-focus X-ray computed tomogram (micro-CT) images showed the modified cement exhibited osteoconduction, which the conventional PMMA bone cement lacked. The percentage fraction of the calcified bone around the modified PMMA bone cement was over 30%, whereas that of the conventional cement was less than 10%. The modification was found to be effective in providing PMMA bone cement with osteoconduction, thus providing probability of stable fixation in a long period after implantation.

聚甲基丙烯酸甲酯（PMMA）骨水泥广泛用于骨科手术中的假体固定;然而，骨与骨水泥之间的界面是一个薄弱区。采用γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MPS）和醋酸钙对PMMA骨水泥进行改性，制备出具有生物活性的PMMA骨水泥。本研究的目的是比较改性骨水泥与传统骨水泥的操作、力学和组织学性能。改良后的骨与种植体之间的结合强度更高。改良PMMA骨水泥的推出载荷在3周内达到1.60 MPa，并在植入后8周内保持不变，而传统骨水泥的推出载荷在整个研究期间均保持较低。组织学观察和微焦点X线计算机断层扫描（micro-CT）图像显示，改性骨水泥具有骨传导性，而传统PMMA骨水泥缺乏。改性PMMA骨水泥周围的钙化骨百分比超过30%，而常规骨水泥周围的钙化骨百分比小于10%。发现这种改良可有效提供具有骨传导性的PMMA骨水泥，从而提供植入后长期稳定固定的可能性。