Non-verbal Communication Method Based on a Biochemical Marker for Children with Severe Motor and Intellectual Disabilities

患有严重运动和智力残疾（SMID）的儿童智商低于35，他们的身体残疾太严重，无法自愿走动，以至于他们躺在床上或几乎不能坐起来。我们一直在尝试开发一种新的非侵入性的手持监测交感神经活动的基础上的医学观察，表明唾液α-淀粉酶的活性的变化响应于交感神经系统的活动的变化。本研究的目的是通过监测SMID儿童交感神经活动的变化来建立一种非语言交流方法。为了实现这一目标，我们开发了一种评估模型，作为一种基本工具，我们可以用它来测量人类的情绪状态，即所谓的人类情绪监测系统，并在临床试验中检验了其功效。 ...更多信息 e研究的对象。治疗前后同时测定唾液淀粉酶活性（sAMY）和心率（交换）。观察到治疗（换管）后sAMY显著增加，平均增加70%。这种增加被证明是心率的两倍以上，并且与通过结构方程模型（SEM）确定的疼痛强度高度相关。此外，为了探讨使用sAMY检测SMID儿童生理变化的可能性，我们定量检测并比较了SMID儿童与正常健康受试者的应激诱导的生理反应。结果发现，患有SMID的儿童和健康受试者之间的生物标志物（sAMY）的绝对值没有显著差异。然而，有一个建议，在SMID的儿童的反应略小于健康的subjects.The目前的研究表明，一种新的，非语言的沟通方法，可以开发的SMID的儿童。因此，目前的研究结果已在科学期刊的5份出版物和国家会议上的介绍中报告。此外，我们已经为我们开发的分析sAMY的方法申请了专利。我们非常期待当前研究的结果不仅能帮助SMID儿童恢复身体和智力功能，防止身体变形，还能提高他们的生活质量（QOL），并教育他们的家人提供知情同意。少

Children with severe motor and intellectual disabilities (SMID) have an IQ of less than 35 and their physical disability is too severe for them to move around voluntarily, so much so, that they remain in bed or barely sit up. We have been attempting to develop a new noninvasive hand-held monitor for sympathetic nerve activity based on the medical observation which shows that the activity of salivary alpha-amylase alters in response to changes in the activity of the sympathetic nervous system. The aim of this study is to establish for a nonverbal communication method for SMID children by monitoring the changes in their sympathetic nerve activity. In order to achieve this goal, we have developed, as a basic tool, an evaluation model with which we can measure the emotional status of humans, a so-called human emotion monitoring system, and have examined its efficacy in clinical trials.Children with SMID requiring frequent exchanges of gastric and/or bronchial tubes on a daily basis were th … More e subjects of the study. The salivary amylase activity (sAMY) and heart rate of the children were measured simultaneously both before and after treatment (exchange). It was observed that the sAMY increased significantly after treatment (tube exchange) with a mean increase of 70%. This increase was shown to be more than twice that of the heart rate and to be highly correlated with the intensity of pain determined by structural equation modeling (SEM). Moreover, in order to investigate the possibility of detecting the physiological changes in children with SMID using sAMY, we quantitatively examined and compared the stressor-induced physiological reactions of children with SMID with normal healthy subjects. As a result, it was found that there was no significant difference in the absolute values of the biomarker (sAMY) between children with SMID and healthy subjects. However, there was a suggestion that the response in the children with SMID was slightly smaller than healthy subjects.The current study suggests that a novel, nonverbal communication method could be developed for children with SMID. Thus, the results of the current study have been reported in 5 publications in scientific journals and presentations at national meetings. In addition, we have applied for a patent for the method we have developed for analyzing sAMY. We have great expectations that the results in the current study will not only assist children with SMID in recovering their physical and intellectual functions and prevent deformation of their bodies, but will also improve their quality of life (QOL) as well as educate their family in providing informed consent. Less