Rapid brain cooling method for acute cerebral ischemia・focal cerebral cooling by cold crystaloid intra-arterial perfusion in canine-

犬急性脑缺血的快速脑冷却方法·冷晶体动脉内灌注局部脑冷却

基本信息

  • 批准号:
    17591538
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2006
  • 项目状态:
    已结题

项目摘要

Purpose: Cerebral hypothermia is the most potent neuroprotectant. Nevertheless, systemic hypothermia may result in fatal complication. It is hypothesized that selective cerebral cooling while maintaining normal core temperature would enable local hypothermic neuroprotection without the stress and side effects of systemic hypothermia. Thus, we have developed a novel method by which the rapid and selective reduction of brain temperature could achieve by intra-arterial perfusing cold crystalloid solution. Method: The experiments were performed on six adult healthy beagle dogs, weighting 10.2-11.4kg, and conducted in accordance with institutional Policies and Guidelines for Care and Use of Laboratory Animals. Ringer's solution cooled to 4 degree centigrade was infused by 1.5-2.0 ml/min/kg via 4Fr catheter intra-arterially. Excessive water was drawn out with hemo-filtration system. Bilateral brain tissue temperatures, rectal temperature, central venous temperature, brain tissue oxygen press … More ure and cardiac output were measured continuously. Several dogs were killed 10 weeks later and pathologically investigated. Results: The brain tissue temperature was fallen into 28 degree centigrade by perfusion for 23.3±7.7min and could be maintained for 106± 13.7min. The contra-lateral brain temperature, core temperature were cooled into less than 34 degree centigrade. The same quantity of perfusate was drawn out by hemo-filtration. The systemic arterial pressure, heart rate and cardiac index were not fluctuated. Pathological findings revealed not any ischemic damages pathologically. Conclusions: The data demonstrated that the intra-arterial cold crystalloid perfusion was technically feasible and useful for selective brain hypothermia, and target temperature are easily controlled. The induction of hypothermia was rapid and maintained for a long period of time, whereas the body temperature was maintained within the normal range and without hemodynamic instability. This method enables us to cool the objective region of the brain selectively, rapidly and safely. This method may useful for acute brain damages, ischemia or refractory epilepsy. Less
目的:脑低温是最有效的神经保护剂。然而,全身低温可能导致致命的并发症。假设在维持正常核心温度的同时进行选择性脑冷却将能够实现局部低温神经保护,而没有全身低温的压力和副作用。因此,我们开发了一种新的方法,通过该方法可以通过动脉内灌注冷晶体溶液来实现快速和选择性地降低脑温度。方法:实验在6只成年健康比格犬(体重10.2-11.4kg)上进行,并按照实验动物护理和使用的机构政策和指南进行。经4Fr导管以1.5- 2.0ml/min/kg的速率动脉内输注冷却至4 ℃的林格氏液。用血液滤过系统抽出过量的水。双侧脑组织温度、直肠温度、中心静脉温度、脑组织氧分压 ...更多信息 连续测量尿素和心输出量。10周后处死几只狗,进行病理学研究。结果:灌注23.3±7.7min,脑组织温度降至28 ℃,可维持106± 13.7min。将对侧脑温、体核温降至34 ℃以下。通过血液滤过抽出相同量的灌注液。体循环动脉压、心率、心脏指数无明显波动。病理结果显示无任何缺血性损害的病理。结论:结果表明,动脉内冷晶体灌注是一种可行的选择性脑低温治疗方法,且靶区温度易于控制。低温的诱导是快速的,并维持了很长一段时间,而体温保持在正常范围内,没有血流动力学不稳定。这种方法使我们能够选择性、快速、安全地冷却大脑的目标区域。该方法可用于急性脑损伤、缺血或难治性癫痫。少

项目成果

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AOKI Atsushi其他文献

Institutionalism in Sung Legal Culture : What's unique and What's not about Chinese Way of Land Transaction
宋代法律文化中的制度主义:中国土地交易方式的独特与不足
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    青木敦;小川快之;斯波義信;J.P.Mcdermott;小島毅ほか;南埜猛;青木 敦;本田治;神吉和夫;AOKI Atsushi;青木 敦;神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);松田吉郎;小川 快之;本田治;松田吉郎;青木敦;本田治;松田吉郎;青木敦;松田吉郎;青木敦;神吉和夫;神吉和夫;神吉和夫;青木敦;Aoki Atsushi
  • 通讯作者:
    Aoki Atsushi
水の娯樂-寧波の例-
水上娱乐-宁波为例-
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    青木敦;小川快之;斯波義信;J.P.Mcdermott;小島毅ほか;南埜猛;青木 敦;本田治;神吉和夫;AOKI Atsushi;青木 敦;神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);松田吉郎;小川 快之;本田治;松田吉郎;青木敦;本田治;松田吉郎;青木敦;松田吉郎;青木敦;神吉和夫;神吉和夫;神吉和夫;青木敦;Aoki Atsushi;神吉和夫;青木敦;青木敦;松田吉郎;本田治;青木敦;青木敦;知野泰明・神吉和夫;青木 敦;松田吉郎;青木敦;松田吉郎;青木敦;青木敦;本田治;松田吉郎;青木敦;本田治;神吉和夫;本田 治;青木敦;南埜猛;青木敦;神吉和夫;青木敦;松田吉郎;青木敦;松田吉郎
  • 通讯作者:
    松田吉郎
源平の争乱
源平之战
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    青木敦;小川快之;斯波義信;J.P.Mcdermott;小島毅ほか;南埜猛;青木 敦;本田治;神吉和夫;AOKI Atsushi;青木 敦;神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);神吉和夫;神吉和夫;高橋 芳郎(津田 芳郎);松田吉郎;小川 快之;本田治;松田吉郎;青木敦;本田治;松田吉郎;青木敦;松田吉郎;青木敦;神吉和夫;神吉和夫;神吉和夫;青木敦;Aoki Atsushi;神吉和夫;青木敦;青木敦;松田吉郎;本田治;青木敦;青木敦;知野泰明・神吉和夫;青木 敦;松田吉郎;青木敦;松田吉郎;青木敦;青木敦;本田治;松田吉郎;青木敦;本田治;神吉和夫;本田 治;青木敦;南埜猛;青木敦;神吉和夫;青木敦;松田吉郎;青木敦;松田吉郎;松田吉郎;南埜猛;王瑞来;神吉和夫・松田吉郎;小川快之;高橋芳郎;上杉和彦
  • 通讯作者:
    上杉和彦
日本西洋史学会第54回大会記「シンポジウム」
日本西洋史学会第54届代表大会「座谈会」
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    田村栄子;牟田麻里耶;熊野直樹;渡辺紘良;山本 文彦;熊野直樹;青木敦;渋谷 聡;渡辺昭一;石田勇治;AOKI Atsushi;渡辺昭一
  • 通讯作者:
    渡辺昭一
The Review on The Tentacles of Progress by D.Headrick, Oxford,1988, Shakai -
《进步的触手》评论,D.Headrick,牛津,1988 年,Shakai -
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    田村栄子;牟田麻里耶;熊野直樹;渡辺紘良;山本 文彦;熊野直樹;青木敦;渋谷 聡;渡辺昭一;石田勇治;AOKI Atsushi;渡辺昭一;渋谷 聡;WATANABE Hiroyoshi;石田勇治;渡辺昭一;Ryoichi NAGATA;石田勇治;斯波義信;Shoichi Watanabe;Yoshihiko ONO;斯波義信;Haruhiko HOSHINO;Shoichi Watanabe
  • 通讯作者:
    Shoichi Watanabe

AOKI Atsushi的其他文献

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{{ truncateString('AOKI Atsushi', 18)}}的其他基金

Basic study on outbreak and development in the Kamakura era of local Buddhist statue
镰仓时代地方佛像的爆发与发展基础研究
  • 批准号:
    25370137
  • 财政年份:
    2013
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research on a Buddhist statue creation sphere in the Shikoku region, and the process of its formation.
四国地区佛教造像圈及其形成过程研究。
  • 批准号:
    22520108
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Formation of Kamakura Buddhism and a Buddha Sculptor Kaikei : Study on Images of Belief and their Makings
镰仓佛教的形成与佛像雕刻家佳庆:信仰形象及其形成的研究
  • 批准号:
    19520105
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Rethinking changes and regional differences in Chinese legal culture
反思中国法律文化的变迁与地域差异
  • 批准号:
    17083013
  • 财政年份:
    2005
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Research on the boarders of the governed district of Hunan and Kiangsi in the Sung period
宋代湘赣辖区边界研究
  • 批准号:
    16520416
  • 财政年份:
    2004
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Preparation of π-Conjugated Polymer Ultrathin Films and their Application to Organic Nanodevices
π共轭聚合物超薄膜的制备及其在有机纳米器件中的应用
  • 批准号:
    15550157
  • 财政年份:
    2003
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Role of the gut microbiota in acute cerebral ischemia
肠道微生物群在急性脑缺血中的作用
  • 批准号:
    15K07439
  • 财政年份:
    2015
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of a novel diagnostic imaging marker in acute cerebral ischemia
急性脑缺血新型诊断成像标志物的开发
  • 批准号:
    15K15464
  • 财政年份:
    2015
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Development of regional brain hypothremia by trans-ventricular and trans-arterial cold infusion in acute cerebral ischemia
经心室和经动脉冷输注治疗急性脑缺血引起的局部脑低体温
  • 批准号:
    24592110
  • 财政年份:
    2012
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
New therapeutic strategy with SMTP for acute cerebral ischemia
SMTP治疗急性脑缺血新策略
  • 批准号:
    23791582
  • 财政年份:
    2011
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT
急性脑缺血大鼠T1RHO和T2RHO MRI WTR动力学研究
  • 批准号:
    8362879
  • 财政年份:
    2011
  • 资助金额:
    $ 2.24万
  • 项目类别:
STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT
急性脑缺血大鼠T1RHO和T2RHO MRI WTR动力学研究
  • 批准号:
    8170484
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
STUDIES OF WTR DYNAMICS BY T1RHO AND T2RHO MRI IN ACUTE CEREBRAL ISCHEMIA RAT
急性脑缺血大鼠T1RHO和T2RHO MRI WTR动力学研究
  • 批准号:
    7955021
  • 财政年份:
    2009
  • 资助金额:
    $ 2.24万
  • 项目类别:
Therapeutic benefits of the genetically-engineering mesenchymal stem cells for sub-acute cerebral ischemia
基因工程间充质干细胞治疗亚急性脑缺血的疗效
  • 批准号:
    20390388
  • 财政年份:
    2008
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
IDENTIFYING PRE-DIABETES IN THE SETTING OF ACUTE CEREBRAL ISCHEMIA
在急性脑缺血的情况下识别糖尿病前期
  • 批准号:
    7603840
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
Importance of treatment of cerebral white matter damage following acute cerebral ischemia
急性脑缺血后脑白质损伤治疗的重要性
  • 批准号:
    19591825
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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