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New therapeutic strategy with SMTP for acute cerebral ischemia

New therapeutic strategy with SMTP for acute cerebral ischemia
SMTP治疗急性脑缺血新策略
批准号：
23791582
负责人：
SAITO Atsushi
金额：
$2.66万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791582/
关键词：
実験脳外科学脳梗塞国際情報交流

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英文摘要
We evaluated effectiveness of SMTP for acute cerebral ischemia using mouse transient focal cerebral ischemia model. SMTP was intravenously injected and successfully reduced size of cerebral infarction compared with the vehicle group. Cerebral blood flow analysis demonstrated that SMTP reduced remarkable increase of CBF after reperfusion and induced gradual CBF recovery. Superoxide production, radical reactive production and endothelial destruction marker was significantly reduced in SMTP-treated group compared with the vehicle group. Our results indicate that SMTP administration might induce not only fibrinolytic effectiveness, but also anti-oxidative injury after reperfusion due to transient cerebral ischemia.
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Stachybotrys microspora triprenyl phenol-7 (SMTP-7) attenuates reperfusion injury after transient focal cerebral ischemia in rats
小孢葡萄穗霉三烯基苯酚 7 (SMTP-7) 减轻大鼠短暂局灶性脑缺血后的再灌注损伤
DOI： --
发表时间： 2012
期刊： Neuroscience Letter
影响因子： --
作者： [Akamatsu Y, Saito A et al]
通讯作者： Saito A et al
Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain
DOI： 10.1016/j.neulet.2011.08.018
发表时间： 2011-10-03
期刊： NEUROSCIENCE LETTERS
影响因子： 2.5
作者： [Akamatsu, Yosuke, Saito, Atsushi, Tominaga, Teiji]
通讯作者： Tominaga, Teiji
Development of 100 W-class superconducting transmit filter
  • 批准号：
    24560393
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.41万
  • 财政年份：
    2012
  • 负责人：
    SAITO Atsushi
  • 依托单位：
    Yamagata University
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    23791921
  • 项目类别：
    Grant-in-Aid for Young Scientists (B)
  • 资助金额：
    $2.16万
  • 财政年份：
    2011
  • 负责人：
    SAITO Atsushi
  • 依托单位：
    Kyoto Prefectural University of Medicine
A study on the mechanisms involved in the invasion of host cells by periodontal pathogens and the novel method for its regulation
  • 批准号：
    22592317
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.25万
  • 财政年份：
    2010
  • 负责人：
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  • 依托单位：
    Tokyo Dental College
The analysis of the differentiation and function of the cells in central nervous system regulated by endoplasmic reticulum stress response.
  • 批准号：
    22800049
  • 项目类别：
    Grant-in-Aid for Research Activity Start-up
  • 资助金额：
    $2.01万
  • 财政年份：
    2010
  • 负责人：
    SAITO Atsushi
  • 依托单位：
    Hiroshima University
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