New therapeutic strategy with SMTP for acute cerebral ischemia

SMTP治疗急性脑缺血新策略

• 批准号: 23791582
• 负责人: SAITO Atsushi
• 金额: $ 2.66万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791582/
• 关键词: 実験脳外科学; 脳梗塞; 国際情報交流

We evaluated effectiveness of SMTP for acute cerebral ischemia using mouse transient focal cerebral ischemia model. SMTP was intravenously injected and successfully reduced size of cerebral infarction compared with the vehicle group. Cerebral blood flow analysis demonstrated that SMTP reduced remarkable increase of CBF after reperfusion and induced gradual CBF recovery. Superoxide production, radical reactive production and endothelial destruction marker was significantly reduced in SMTP-treated group compared with the vehicle group. Our results indicate that SMTP administration might induce not only fibrinolytic effectiveness, but also anti-oxidative injury after reperfusion due to transient cerebral ischemia.

采用小鼠短暂性局灶性脑缺血模型评价SMTP治疗急性脑缺血的有效性。与溶剂组相比，静脉注射SMTP成功地减小了脑梗死的大小。脑血流量分析表明，SMTP可减少再灌注后CBF的显著增加，并使CBF逐渐恢复。与溶剂组相比，SMTP处理组的超氧化物生成、自由基反应生成和内皮破坏标记物显著减少。我们的研究结果表明，SMTP管理可能不仅诱导纤溶的有效性，但由于短暂性脑缺血再灌注后的抗氧化损伤。

项目成果

Stachybotrys microspora triprenyl phenol-7 (SMTP-7) attenuates reperfusion injury after transient focal cerebral ischemia in rats

小孢葡萄穗霉三烯基苯酚 7 (SMTP-7) 减轻大鼠短暂局灶性脑缺血后的再灌注损伤

• 发表时间: 2012
• 期刊: Neuroscience Letter
• 作者: Akamatsu Y;Saito A et al
• 通讯作者: Saito A et al

Stachybotrys microspora triprenyl phenol-7, a novel fibrinolytic agent, suppresses superoxide production, matrix metalloproteinase-9 expression, and thereby attenuates ischemia/reperfusion injury in rat brain

• DOI: 10.1016/j.neulet.2011.08.018
• 发表时间: 2011-10-03
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Akamatsu, Yosuke;Saito, Atsushi;Tominaga, Teiji
• 通讯作者: Tominaga, Teiji