Elucidate the role of BMP and BMP antagonist USAG-1 in the progression of chronic kidney diseases and therapeutic application

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Dialysis dependency is one of the leading causes of morbidity and mortality in the world, and once end-stage renal disease develops, it cannot be reversed by currently available therapy. Although the administration of large dose of bone morphogenetic protein7 (BMP7) has been shown to repair established renal injuries and improves renal function, pathophysiological role of endogenous BMP7 and regulatory mechanism of its activities remain elusive. Here we show that uterine sensitization-associated gene-1 (USAG-1), novel BMP antagonist abundantly expressed in the kidney, is the central negative regulator of BMP function in the kidney, and that inhibition of USAG-1 will be promising therapeutic trial for kidney diseases.