The role of temperature in the origin and evolutionary success of Arabidopsis polyploids

全基因组重复（WGD）是一种普遍存在的影响多样化、适应性和农业的大突变。WGD在全球范围内与低温有关，但寒冷环境是否会触发多倍体的形成，或者为多倍体范围扩大和适应提供机会，仍有待检验。利用主要植物模型拟南芥的四种自然WGD转换，我们将在自然环境中解决这两个假设。通过将欧亚大陆范围内的采样与操作实验相结合，我们将测试环境温度对所有谱系中新多倍体形成率的影响。然后，我们将把实验与群体基因组模型结合起来，以测试对寒冷环境的适应是否有助于多倍体的成功。这样一个跨学科的提案将受益于两个团队在实验、核学、短链和连锁阅读基因组学方面的互补专业知识。我们的结果将告知大突变在适应环境挑战中的作用，反过来，恶劣环境对大突变率的影响。

Whole-genome duplication (WGD) is a ubiquitous macromutation affecting diversification,adaptation, and agriculture. WGD is globally associated with low temperatures, yet it remains to be tested if cold environments trigger polyploid formation or rather provide an opportunity for polyploid range expansion and adaptation. Leveraging four natural WGD transitions in leading plant model Arabidopsis, we will address these two hypotheses in a natural context. By combining our Eurasia-wide sampling with manipulative experiments we will test the effect of ambient temperature on the rates of neopolyploid formation across all lineages. Then, we will integrate experiments with population genomic modelling to test if adaptation to cold environments contributes to polyploid success. Such an interdisciplinary proposal will benefit from complementary expertise of both teams in experiments, karyology, short- and linked-read genomics. Our results will inform on the role of macromutations in adaptation to environmental challenges and, in turn, the effect of harsh environments on the rates of macromutations.