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Design of chemical valve system based on the concept of molecular-specific synchronization

基于分子特异性同步概念的化工阀门系统设计

基本信息

批准号：
11167210
负责人：
KATAOKA Kazunori
金额：
$ 31.68万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2002
项目状态：
已结题

项目摘要

The objective of this study is to construct chemical-valve system based on the concept of molecular synchronization. For this purpose, two-types of materials systems were examined here : (1)Networked structure of polymers (polymeric gels) and (2)nano-associates of block copolymers (polymeric micelles). The former system was focused on the development of materials undergoing abrupt change in their volume at physiological condition responding to external glucose concentration. A basis of the system studied here is the shift in the equilibrium between the uncharged and charged form of phenylboronic acid moieties in the polymer chain thorough complex formation with glucose. An increased glucose-concentration shifts the equilibrium in the direction of increasing fraction of borate anions and decreasing the fraction of the uncharged form. Charged borates are certainly more hydrophilic than the uncharged form. Thus, a glucose-dependent change in the ratio between uncharged and charged borates in the polymer chain should crucially affect the polymer solubility, if the polymer chain has an amphiphilic character. Apparently, this materials system should be useful to construct self-regulating insulin-releasing device for the treatment of diabetes. The latter system was designed to dissociate upon its internalization into the intracellular compartment so as to release cargo compounds selectively inside of target cells. These stimuli-sensitive polymeric micelles should be useful as nanocanrriers for gene and drug delivery.

本研究的目的是基于分子同步化的概念构建化学阀系统。为此，本文研究了两类材料体系：（1）聚合物的网络结构（聚合物凝胶）和（2）嵌段共聚物的纳米缔合物（聚合物胶束）。前一个系统的重点是在生理条件下响应于外部葡萄糖浓度而发生体积突变的材料的开发。在这里研究的系统的基础是移动之间的平衡的不带电和带电的形式的苯基硼酸部分的聚合物链中通过与葡萄糖形成复合物。增加的葡萄糖浓度在增加硼酸根阴离子的分数和减少不带电形式的分数的方向上移动平衡。带电荷的硼酸盐当然比不带电荷的硼酸盐更亲水。因此，如果聚合物链具有两亲特性，则聚合物链中不带电和带电硼酸盐之间的比率的葡萄糖依赖性变化应该对聚合物溶解度产生关键影响。该材料体系有望用于构建治疗糖尿病的自调节胰岛素释放装置。后一种系统被设计成在其内化到细胞内隔室中时解离，以便在靶细胞内选择性地释放货物化合物。这些刺激敏感的聚合物胶束应该可用作基因和药物递送的纳米载体。