Polymeric micelle nanocarrier for drug and gene delivery

用于药物和基因递送的聚合物胶束纳米载体

• 批准号: 17016017
• 负责人: KATAOKA Kazunori
• 金额: $ 29.57万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016017/
• 关键词: ドラッグデリバリー; ナノキャリア; 高分子ミセル; がん化学療法; 遺伝子治療; siRNA; ナノテクノロジー; がん治療; 化学療法; がん標的治療

To realize the targeting therapy against intractable tumors, we developed functional polymeric micelles integrated with the sensitivity to intracellular low pH conditions and the ability to bind the specific cells for the delivery of antitumor agents, and demonstrated their effectiveness in the in vivo study using tumor-bearing mice. Also, to establish the molecular cancer therapy based on gene delivery, we developed a non-viral gene vector based on polymeric micelles stabilized through the cross-linking cleavable under the intracellular reductive conditions, and succeeded in their application to antiangiogenic cancer therapy.

为了实现对难治性肿瘤的靶向治疗，我们开发了功能性聚合物胶束，该胶束集成了对细胞内低pH条件的敏感性和结合特异性细胞的能力，用于递送抗肿瘤药物，并在荷瘤小鼠的体内研究中证明了它们的有效性。此外，为了建立基于基因递送的分子癌症治疗，我们开发了基于聚合物胶束的非病毒基因载体，该聚合物胶束通过在细胞内还原条件下可裂解的交联而稳定，并成功地将其应用于抗血管生成癌症治疗。

项目成果

Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing alphavbeta3 and alphavbeta5 integrins.

• 发表时间: 2007
• 期刊: Bioconjugate chemistry
• 影响因子: 4.7
• 作者: M. Oba;S. Fukushima;N. Kanayama;K. Aoyagi;N. Nishiyama;H. Koyama;K. Kataoka

Enhanced transfection with silica-coated polyplexes loading plasmid DNA

使用装载质粒 DNA 的二氧化硅包被的复合物增强转染

• 发表时间: 2010
• 期刊: Biomaterials 31
• 作者: K.Miyata;K.Kataoka;et al.
• 通讯作者: et al.

Gene delivery with biocompatible cationic polymer: Pharmacogenomic analysis on cell bioactivity

• DOI: 10.1016/j.biomaterials.2007.07.019
• 发表时间: 2007-12-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Masago, Kayo;Itaka, Keiji;Kataoka, Kazunori
• 通讯作者: Kataoka, Kazunori

Versatile and Selective Synthesis of "Click Chemistry" Compatible Heterobifunctional Poly(ethylene glycol)s Possessing Azide and Alkyne Functionalities

• DOI: 10.1021/bc900253p
• 发表时间: 2010-02-01
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Hiki, Shigehiro;Kataoka, Kazunori
• 通讯作者: Kataoka, Kazunori

In vivo antitumor activity of the folate-conjugated pH-Sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments

• DOI: 10.1021/bc060401p
• 发表时间: 2007-07-01
• 期刊: BIOCONJUGATE CHEMISTRY
• 影响因子: 4.7
• 作者: Bae, Younsoo;Nishiyama, Nobuhiro;Kataoka, Kazunori
• 通讯作者: Kataoka, Kazunori