Polymeric micelle nanocarrier for drug and gene delivery

为了实现对难治性肿瘤的靶向治疗，我们开发了对细胞内低pH条件的敏感性和结合特定细胞以输送抗肿瘤药物的功能性聚合物胶束，并在荷瘤小鼠的体内研究中证明了其有效性。此外，为了建立基于基因传递的分子肿瘤治疗，我们开发了一种基于在细胞内还原条件下通过交联裂解而稳定的聚合物胶束的非病毒基因载体，并成功地将其应用于抗血管生成肿瘤的治疗。

To realize the targeting therapy against intractable tumors, we developed functional polymeric micelles integrated with the sensitivity to intracellular low pH conditions and the ability to bind the specific cells for the delivery of antitumor agents, and demonstrated their effectiveness in the in vivo study using tumor-bearing mice. Also, to establish the molecular cancer therapy based on gene delivery, we developed a non-viral gene vector based on polymeric micelles stabilized through the cross-linking cleavable under the intracellular reductive conditions, and succeeded in their application to antiangiogenic cancer therapy.