Analysis and control of the fluids, interfaces of liquid-liquid and liquid-solid in microchannels

微通道内流体、液-液、液-固界面分析与控制

• 批准号: 13124209
• 负责人: SHOJI Shuichi
• 金额: $ 16.64万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13124209/
• 关键词: Microcell; Micro Total Analysis Systems; Microreactor; Microfluidics; Microflow observation; Micromachining; Finite element model flow analysis; Interface control; 微量流体制御; 流体解析; 蛍光観察; 液体-液体界面; 固体-液体界面

Nano/micro flow systems open up the new possibilities for chemical and biochemical analysis and synthesis. For the design of nano/micro flow systems LSI designing concepts is applicable considering the symmetries between the electric devices and the flow devices. Nano/micro flow devices and elements which have micro meter scale sizes and nano liter volumes developed so far are described. Microvalves of negligible leakage and dead volumes were developed for chemical/biochemical applications. Micro mixers and sample injectors were obtained by using microfluidic behaviors in micro scale channels. In channel micro filters and electrochemical biosensors were fabricated using high aspect ratio UV photolithographic technologies. 3D metal electrodes implanted PDMS microflow cell was fabricated using 3D assembly method. Biological cell observation micro cell integrated on chip microvalve for regent injection was fabricated on Si substrate using deep RIE. Biomolecules sorting microsystems were. also realized using sol-gel transfer of hydrogels.

纳米/微米流动系统为化学和生物化学分析和合成开辟了新的可能性。对于纳/微流系统的设计，考虑到电子器件和流器件之间的对称性，LSI设计概念是适用的。描述了迄今为止开发的具有微米级尺寸和纳升体积的纳米/微米流动装置和元件。微阀的泄漏和死体积可以忽略不计的化学/生物化学应用。利用微尺度通道内的微流体行为，得到了微混合器和进样器。采用高纵横比紫外光固化技术制备了通道内微过滤器和电化学生物传感器。采用三维组装方法制备了三维金属电极植入PDMS微流池。采用深反应离子刻蚀技术在硅基片上制作了生物细胞观察微池，并将其集成在芯片上，实现了试剂注入用微阀。生物分子分选微系统。也可以使用水凝胶的溶胶-凝胶转移来实现。

项目成果

Y.Shirasaki, H.Makazu, S.lkeda, S.Shoji, T.Funatsu: "A Novel Biomolecule Sorter Using Thermosensitive Hydrogel in Micro Flow Systems"Proc. Micro Total Analysis Systems 2002 ; mTAS2002. Vol.2. 925-927 (2002)

Y.Shirasaki、H.Makazu、S.lkeda、S.Shoji、T.Funatsu：“在微流系统中使用热敏水凝胶的新型生物分子分选机”Proc。

S.Shoji, K.Tashiro, T.Sekiguchi, H.Sato, N.Honda, T.Funatu: "Lab-on-a-chip, Miniaturies Systems for (Bio) Chemical Anaysis and Synthesis"Elsevier B.V., Amsterdam. 205-214 (2003)

S.Shoji、K.Tashiro、T.Sekiguchi、H.Sato、N.Honda、T.Funatu：“用于（生物）化学分析和合成的芯片实验室微型系统”Elsevier B.V.，阿姆斯特丹。

M.Kanai, S.Ikeda, J.Tanaka, J.S.Go, H.Nakanishi, S.Shoji: "The multiple sample injector using improved sheath flow to prevent sample dilution"Sensors & Actuators A. Vol.111. 32-36 (2004)

M.Kanai、S.Ikeda、J.Tanaka、J.S.Go、H.Nakanishi、S.Shoji：“使用改进的鞘流来防止样品稀释的多样品注射器”传感器

K.Tashiro, S.Ikeda, T.Sekiguchi, H.Sato, S.Shoji: "Micro Flow Switches Using Thermal Gelation of Methyl Cellulose for Biomolecules Handling"Dig. 11<th> Int. Conf. on Solid-State Sensors & Actuators ; Transducers'01. Vol.2. 932-935 (2001)

K.Tashiro、S.Ikeda、T.Sekiguchi、H.Sato、S.Shoji：“利用甲基纤维素热凝胶化进行生物分子处理的微流量开关”Dig。

T.Homma, L.Komatsu, A.Tamaki, H.Nakai, T.Osaka: "Molecular Orbital Study on the Reaction Mecha-nisms of Electroless Deposition Processes"Electrochim. Acta. 47(1-2). 47-53 (2001)

T.Homma、L.Komatsu、A.Tamaki、H.Nakai、T.Osaka：“无电沉积过程反应机制的分子轨道研究”Electrochim。