Analysis and control of the fluids, interfaces of liquid-liquid and liquid-solid in microchannels

微通道内流体、液-液、液-固界面分析与控制

• 批准号: 13124209
• 负责人: SHOJI Shuichi
• 金额: $ 16.64万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13124209/
• 关键词: Microcell; Micro Total Analysis Systems; Microreactor; Microfluidics; Microflow observation; Micromachining; Finite element model flow analysis; Interface control; 微量流体制御; 流体解析; 蛍光観察; 液体-液体界面; 固体-液体界面

Nano/micro flow systems open up the new possibilities for chemical and biochemical analysis and synthesis. For the design of nano/micro flow systems LSI designing concepts is applicable considering the symmetries between the electric devices and the flow devices. Nano/micro flow devices and elements which have micro meter scale sizes and nano liter volumes developed so far are described. Microvalves of negligible leakage and dead volumes were developed for chemical/biochemical applications. Micro mixers and sample injectors were obtained by using microfluidic behaviors in micro scale channels. In channel micro filters and electrochemical biosensors were fabricated using high aspect ratio UV photolithographic technologies. 3D metal electrodes implanted PDMS microflow cell was fabricated using 3D assembly method. Biological cell observation micro cell integrated on chip microvalve for regent injection was fabricated on Si substrate using deep RIE. Biomolecules sorting microsystems were. also realized using sol-gel transfer of hydrogels.

纳米/微流系统为化学和生化分析和合成开辟了新的可能性。对于纳米/微流系统的设计，LSI设计概念是适用的，考虑到电动设备与流动设备之间的对称性。描述了到目前为止，纳米/微流设备和具有微米尺寸和纳米升量的元素。为化学/生化应用开发了可忽略不计的泄漏和死量的微牛。通过在微尺度通道中使用微流体行为获得微型混合器和样品注射器。在通道中，微滤波器和电化学生物传感器是使用紫外线光刻技术制造的。使用3D组装方法制造了3D金属电极植入的PDMS微流元素。使用Deep Rie在SI底物上制造了在芯片微源地上整合的生物细胞观测微细胞进行摄政注射。生物分子分类微型系统是。还使用水凝胶的溶胶 - 凝胶转移实现。

项目成果

S.Shoji, K.Tashiro, T.Sekiguchi, H.Sato, N.Honda, T.Funatu: "Lab-on-a-chip, Miniaturies Systems for (Bio) Chemical Anaysis and Synthesis"Elsevier B.V., Amsterdam. 205-214 (2003)

S.Shoji、K.Tashiro、T.Sekiguchi、H.Sato、N.Honda、T.Funatu：“用于（生物）化学分析和合成的芯片实验室微型系统”Elsevier B.V.，阿姆斯特丹。

M.Kanai, S.Ikeda, J.Tanaka, J.S.Go, H.Nakanishi, S.Shoji: "The multiple sample injector using improved sheath flow to prevent sample dilution"Sensors & Actuators A. Vol.111. 32-36 (2004)

M.Kanai、S.Ikeda、J.Tanaka、J.S.Go、H.Nakanishi、S.Shoji：“使用改进的鞘流来防止样品稀释的多样品注射器”传感器

Y.Shirasaki, H.Makazu, S.lkeda, S.Shoji, T.Funatsu: "A Novel Biomolecule Sorter Using Thermosensitive Hydrogel in Micro Flow Systems"Proc. Micro Total Analysis Systems 2002 ; mTAS2002. Vol.2. 925-927 (2002)

Y.Shirasaki、H.Makazu、S.lkeda、S.Shoji、T.Funatsu：“在微流系统中使用热敏水凝胶的新型生物分子分选机”Proc。

N.Honda, K.Emi, T.Kaxagiri, T.Irita, S.Shoji, H.Sato, T.Homma, T.Osaka, M.Saito: "3-D comb electrodes for amperometric immuno sensors"Conf.On Solid-State Sensors, Actuators and Microsystems : Transducers'03. 2. 1132-1135 (2003)

N.Honda、K.Emi、T.Kaxagiri、T.Irita、S.Shoji、H.Sato、T.Homma、T.Osaka、M.Saito：“用于电流免疫传感器的 3-D 梳状电极”Conf.On

N.Honda, K.Emi, T.Katagiri, T.Irita, S.Shoji, H.Sato, T.Homma, T.Osaka, M.Saito, J.Mizuno, Y.Wada: "3-D comb electrodes for amperometric immuno sensors"12^<th> Int. Conf. On Solid-State Sensors, Actuators and Microsystems : Transducers'03, Boston. Vol.2.

N.Honda、K.Emi、T.Katagiri、T.Irita、S.Shoji、H.Sato、T.Homma、T.Osaka、M.Saito、J.Mizuno、Y.Wada：“3-D 梳状电极