Genetic analyses of intracranial aneurysms

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Saccular intracranial aneurysms (IAs) are balloon-like dilations of the intracranial arterial wall; their hemorrhage results in severe neurologic impairment and death. We identified three new loci showing strong evidence for association with IA. Together, these 5 loci explain ~5% of the genetic risk of IA. It is noteworthy that 3 of these putative risk genes encode regulators of the cell cycle. These findings have implications for the pathogenesis and pre-clinical diagnosis of IA. Despite the gene identification with the largest scale GWAS, the whole picture of the susceptibilities underlying IA is not still uncovered.