Molecular mechanism of the connection between chromosome networks and recombination

减数分裂中的遗传变化是由同源重组驱动的。这种重组不仅产生了基因组的多样性，而且在减数分裂I的染色体分离中起着至关重要的作用。减数分裂重组在机制上不同于有丝分裂，具有更复杂的调控。通过本研究，我们发现了重组过程中的几个关键蛋白/基因，为我们研究减数分裂重组的机制提供了新的思路。特别是，我们已经确定了染色体动力学和结构在控制重组中的积极作用。

Genetic change in meiosis is driven by homologous recombination. The recombination not only generates diversity in the genome, but also plays an essential role in chromosome segregation at meiosis I. Meiotic recombination is mechanistically different from that in mitosis with more complex regulation. From this study, we have identified several key proteins/genes in the recombination which tell us a new idea on the mechanisms of meiotic recombination. Particularly, we have identified an active role of chromosome dynamics and structure in the control of the recombination.