Development of Multi Element Compounding Reaction System by Highly Coordinated Transition Metal Complexes

过渡金属催化的反应已发展成为一种高效、选择性和高产率的碳-碳和碳-硅键形成方法，这些方法通常应用于从材料科学到天然产物合成的广泛领域。过渡金属络合物大致分为中性、阳离子和阴离子络合物。前两种催化剂在学术界和工业界都被广泛用作有机合成催化剂，而后一种催化剂应用较少。中性络合物与有机金属试剂反应形成的阴离子络合物具有较高的电子密度。因此，认为与相应的中性络合物相比，阴离子络合物在金属中心或π-碳配体上的亲核性和给电子能力都将得到提高。通过关注阴离子络合物的这些特性，我们开发了使用烷基卤化物和/或氯硅烷进行碳-碳和碳-硅键形成反应的新方法。

Transition metal-catalyzed reactions have matured into powerful, selective, and high-yielding methods for carbon-carbon and carbon-silicon bond formation, and such processes are routinely used in the wide fields ranging from materials science to natural product synthesis. Transition metal complexes are classified broadly into neutral, cationic, and anionic complexes. The former two have been widely used as catalysts for organic synthesis in both academia and industry while the latter is applicably behind. Anionic complexes formed by the reaction of neutral complexes with organometallic reagents possess high electron densities. Consequently, it is considered that the nucleophilicity at the metal center or π-carbon ligands, and the electron-donating ability of anionic complexes would be enhanced in comparison with the corresponding neutral complexes. We have developed new methodologies for carbon-carbon and carbon-silicon bond forming reactions using alkyl halides and/or chlorosilanes by drawing focus to these characteristics of an anionic complex.