Development of Multi Element Compounding Reaction System by Highly Coordinated Transition Metal Complexes

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Transition metal-catalyzed reactions have matured into powerful, selective, and high-yielding methods for carbon-carbon and carbon-silicon bond formation, and such processes are routinely used in the wide fields ranging from materials science to natural product synthesis. Transition metal complexes are classified broadly into neutral, cationic, and anionic complexes. The former two have been widely used as catalysts for organic synthesis in both academia and industry while the latter is applicably behind. Anionic complexes formed by the reaction of neutral complexes with organometallic reagents possess high electron densities. Consequently, it is considered that the nucleophilicity at the metal center or π-carbon ligands, and the electron-donating ability of anionic complexes would be enhanced in comparison with the corresponding neutral complexes. We have developed new methodologies for carbon-carbon and carbon-silicon bond forming reactions using alkyl halides and/or chlorosilanes by drawing focus to these characteristics of an anionic complex.