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心筋細胞障害の成因と防御に関する基礎的研究

心肌细胞损伤的原因及防护基础研究

基本信息

批准号：
62624003
负责人：
多田道彦
金额：
$ 11.33万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1987
资助国家：
日本
起止时间：
1987 至无数据
项目状态：
已结题

项目摘要

心筋障害の発生・進展過程並びにその防御の問題を, 分子レベルで究明することを目的として, 公募研究16名を含む計59名からなる5計画研究班を発足・組織し, 各々心筋細胞の興奮・収縮機構, 心筋細胞機能の調節・適応と破綻, 細胞損傷・修復過程とその修飾因子, 虚血による障害とその防御細胞機能障害と心作動物質を主課題として研究に着手した. 本総括班の第一の目標は, これら5つの計画研究の効率を高め, その成果をより具体的な形で結実させるために, 研究組織の整合, 学際領域研究の促進を企ることである. 今年度は11月6, 7日の2日間合同班会議を開催し, 全班員が互いに研究進行状況を把握することによって役割分担を再確認すると共に, 臨床医学と基礎生物科学との有機的な研究協力体制を敷く基盤と形成した. 各研究班は心筋細胞機能の生物学的基本原理, 適応と調節, その破綻と防御という段階に分けて集中的に研究を進めつつあるが, 各班に共通する課題については, 随時学術集会をもち討議を尽すことによって, 各計画班の連係を強化した. 今年度は, 2回公開シンポジウムを開催し, 心筋細胞の電気活動とエネルギー代謝, カルシウムイオンと心筋細胞応答の問題を採り上げ, 研究の進展をまとめると共に今後の研究方向性について討議した. 総括班の第二の目標は, 細胞生物学や分子遺伝学の手法や知見が心筋細胞障害の解明にどの程度有効かを徹底的に模索し, その導入を積極的に推進することである. この点については, (1)細胞膜Na,Caチャンネルの構造-機能連関と心筋興奮, (2)心筋興奮収縮連関を可るNa, Ca転送の分子機構, (3)受容体, 伝達器複合体による細胞内情報伝達機構, (4)遺伝子調節による心筋収縮蛋白質の形質変換, を当面の重点課題とし研究を展開させることによって, 心筋機能の物質論的基盤を固めつつある. これら研究分野は, 米国との競争が激しい領域であり, 情報の収集交換も積極的に行った.

In the process of heart disorders, students are involved in the process of prevention and prevention of problems. Molecular scientists have made it clear that the purpose of the study is to study 16 students, including a total of 59 students in the 5 project research class. the organization of the program, the organization of the organization, the organization of the organization, the mechanism of the heart, the mechanism of the heart, the repair of the process, the repair of the factors in the process of repair. The deficiency blood barrier defense cell can block the mental activity unit, the main project, the research program, and the beginning of the study. This course includes the first goal of the class, the high rate of planned research, the specific structure of the results, the integration of research organizations, and the promotion of international research. During the contract class meeting on November 6, 7 and 2 of this year, the contract class meeting was held to urge the whole class to conduct a mutual study to ensure that the sharing of labor and service cutting sharing was confirmed. Bed medicine, medical science, bioscience, research, coordination, research, coordination, research, application, coordination, research, coordination, coordination, application, coordination, application, coordination, coordination, application, coordination and coordination are discussed. Each research class is concerned with the basic principles of biology, the study of the basic principles of biology. This year, two public meetings have been held, and there have been two public reminders on behalf of cell phone activities and questions, research progress and future research directions. In the second part of the class, cell biology, molecular science, molecular science, cell biology, molecular science, molecular science, cell biology, molecular biology, molecular biology, The following steps are required: (1) the membrane Na,Ca device can connect with the heart, (2) the link can be sent to the molecular mechanism by Na,Ca, (3) the acceptor, the complex of the receptor, the intracellular information access machine, and (4) the protein profile of the heart. In the face of key projects, research and development, we will develop a basic research program that can be used in the discussion of materials. There is a distinction between research and development in the United States, and the United States is in a position to compete in the field, exchange feelings, and actively engage in action.