Using marmosets to study the cognitive control of joint attention

利用狨猴研究联合注意力的认知控制

• 批准号: 502356914
• 负责人: Professor Dr. Hans-Peter Thier
• 金额: --
• 依托单位: Abteilung Kognitive Neurologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/502356914?language=en
• 关键词: Using; marmosets; study; cognitive; control

The proposed project tries to unravel the neural underpinnings of joint attention and its context dependent control exploiting the advantages of the flat marmoset cortex that facilitates the usage of ECoG grids for the recording of local field potential activity (lfp) from extended parts of cerebral cortex. The working hypothesis builds on the applicant’s preliminary work on the control of joint attention in human and nonhuman primates and will be tested in marmosets trained to participate in paradigms that tap the animals´ ability to establish joint attention and its executive control. It posits that shifts of attention prompted by the other’s gaze towards an object of joint attention are a consequence of neural interactions in distinct lfp frequency bands in a fronto-temporo-parietal network that involves several hubs with specific functions: the lateral intraparietal area (LIP) is assumed to represent the network output level responsible for releasing a shift of attention to the location of the object of interest to the other. The relevant location is identified by a peak in a salience map of the visual environment in LIP that is the resultant of the convergence of two inputs impinging on LIP, information on the direction of the other’s gaze vector derived from the gaze following patch in temporal cortex and input from the inferior frontal junction area, the latter needed to distinguish the position of the relevant object from the position of distractor objects that may be hit by the same gaze vector. Information on the relevant spatial location and the object as it is thought to be bound by synchronization of activity in LIP and a representation of object features in inferotemporal cortex. Finally, information for the executive control of the observer’s shift of attention towards the object of joint attention is assumed to be drawn from prefrontal cortex.

该项目试图揭示共同注意及其上下文依赖控制的神经基础，利用平坦的狨猴皮层的优势，方便使用ECoG网格来记录大脑皮层扩展部分的局部场电位活动（lfp）。工作假设建立在申请人对人类和非人类灵长类动物共同注意力控制的初步研究基础上，并将在狨猴身上进行测试，这些狨猴经过训练，可以参与利用动物建立共同注意力及其执行控制的能力的范例。该研究假设，由对方注视共同注意的物体引起的注意力转移是额颞顶叶网络中不同lfp频带的神经相互作用的结果，该网络涉及几个具有特定功能的枢纽：侧顶叶内区（LIP）被认为代表负责释放注意力转移到另一个感兴趣的物体位置的网络输出水平。相关峰的位置是确定的显著图在唇的合成视觉环境的融合两个输入侵犯嘴唇,对方的目光的方向向量的信息来源于补丁后的目光从下额颞叶皮层和输入结区,后者需要区分相关对象的位置和错误选择对象的位置可能遭受同样的目光向量。有关空间位置和物体的信息，因为它被认为是由LIP活动的同步和颞下皮层中物体特征的表征所绑定的。最后，对观察者的注意力转移到共同注意对象的执行控制的信息被认为是从前额叶皮层提取的。