Coordination Funds

协调基金

• 批准号: 239650527
• 负责人: Professor Dr. Hans-Peter Thier
• 金额: --
• 依托单位: Abteilung Kognitive Neurologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2019-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/239650527?language=en
• 关键词: Coordination; Funds

The research unit FOR 1847 asks for a second period of funding to enable the scientists involved to continue their joint efforts to promote the understanding of how the human brain realizes complex functions such as perception, communication, or the guidance of movement, a goal that requires a characterization of information processing at multiple levels, from synapses and neurons, to the processing of information in local microcircuits, up to large-scale interactions between distant brain areas. Invasive studies of the brains of non-human primates, used as models of the human brain, play a key role in research on the neuronal underpinnings of higher brain functions. They can take advantage of the similarity of the cognitive and behavioural repertoire of humans and non-human primates and of the underlying brain architectures, which are both direct consequences of the phylogenetic proximity of the two groups. The research unit brought together a group of scientists who try to unravel information processing in the brain of non-human primates underlying complex behaviours, deploying sophisticated combinations of behavioural paradigms and cutting edge neurophysiological, neuropharmacological and optogenetic methods. The group members strongly believe that answering the question of how highly developed brains generate complex functions requires an understanding of both information processing and its differences in distinct neuronal circuits (research group A), as well as an understanding of how signals are exchanged between circuits and areas (research group B). As in the first funding period, the neurobiological research programme will be supplemented by activities to establish and develop the highest standards of animal experimentation and to improve the public,s knowledge and acceptance of this core aspect of modern neuroscience research (primate welfare, ethics, and outreach projects). The very successful graduate training programme will continue to train the next generation of primate neurobiologists. The proposed research unit therefore will provide considerable added value for primate neurobiology not only in terms of scientific but also of structural benefits. The modest changes of the group composition, termination of one rather marginal project (A4) and addition of two new projects (A6 and B5), promise to promote the group coherence and additional momentum for the groups work on the interaction of vision and behaviour.

FOR 1847研究单位请求第二期资助，以使参与其中的科学家能够继续共同努力，促进对人脑如何实现复杂功能（如感知、交流或运动引导）的理解，这一目标需要对多个层面的信息处理进行表征，从突触和神经元，到局部微电路中的信息处理，再到遥远大脑区域之间的大规模相互作用。对非人类灵长类动物大脑（用作人类大脑模型）的侵入性研究在高级大脑功能的神经元基础研究中发挥着关键作用。他们可以利用人类和非人类灵长类动物的认知和行为能力以及潜在的大脑结构的相似性，这些都是两个群体系统发育接近的直接结果。该研究小组聚集了一群科学家，他们试图解开非人类灵长类动物大脑中复杂行为背后的信息处理过程，部署行为范式和尖端神经生理学、神经药理学和光遗传学方法的复杂组合。小组成员坚信，回答高度发达的大脑如何产生复杂功能的问题需要了解信息处理及其在不同神经元回路中的差异（A组研究），以及如何在回路和区域之间交换信号（B研究组）。与第一个资助期一样，神经生物学研究计划将得到建立和发展动物实验最高标准的活动的补充，并提高公众对现代神经科学研究这一核心方面（灵长类动物福利、伦理和外展项目）的了解和接受度。非常成功的研究生培训计划将继续培训下一代灵长类神经生物学家。因此，拟议的研究单位将为灵长类神经生物学提供相当大的附加值，不仅在科学方面而且在结构效益方面。小组组成的适度变化、终止一个相当边缘的项目（A4）和增加两个新项目（A6 和 B5），有望促进小组的一致性，并为小组在愿景和行为互动方面的工作提供额外的动力。