NON-INVASIVE STUDY OF HUMAN BRAIN FUNCTION USING PHYSIOLOGICAL METHODS,MAGNETOENCEPHALOGRAPHY AND ELECTROENCEPHALOGRAPHY

利用生理学方法、脑磁图和脑电图对人脑功能进行非侵入性研究

• 批准号: 07458215
• 负责人: KAKIGI Ryusuke
• 金额: $ 4.86万
• 依托单位: OKAZAKI NATIONAL RESEARCH INSTITUTES
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07458215/
• 关键词: Electroencephalography; Magnetoencehalography; Somatosensory sensation; Visual sensation; Apparent motion; Brain function; 仮現運動; ヒト; 高次脳機能; 痛覚; 双極子; 非侵襲; 温度覚; 神経生理学; 誘発電位

We studied magnetic evoked fields (EF) following somatosensory (SEF) and visual (VEF) stimulation to investigate the mechanisms of sensory perception in terms of temporal and spatial information in the human brain.SEFWe recorded SEF following electrical or mechanical stimulation applied to the scalp, lip, upper limb and lower limb, and reconfirmed "homunculus" in the primary sensory area (SI) reported by Dr. Penfield. In general, receptive fields are consistent with "homunculus", but a large inter-individual difference was found, particularly in the lower limb area in SI.We also found the intra-individual (left-right) difference. We made a new device to produce "passive movement" to investigate cortical activities to the signals ascending through muscle afferent. Both waveforms and activated areas following passive movement of fingers were significantly different from those following electrical or mechanical stimulation applied to the fingers. Probably the difference was due to the fac … More ts that are 3a in SI was activated follwoing a passive movement, but area 3b in SI was activated following electrical or mechanical stimulation.VEFWe used pattern-reversal black and white checker board stimulation to record VEF,mainly to investigate the activated areas in the primary visual cortex (VI) to various visual fields stimulation. At first, we used a half and quadrant field stimulation and confirmed that the retinotopy corresponded to the separation of activated areas in VI.This finding was consistent with a so-called "cruciform model". Next, we recorded VEF following central and peripheral field stimulation. VEF to the central field stimulation was mainly located in the crown of the occipital lobe. It is difficult for VEF to record activities in such areas. In contrast, VEF to the peripheral field stimulation was clearly recorded with a large amplitude. We recorded VEF to the aparent motion, and found activities around the crossing point of the ascending branch of the inferior temporal sulcul and lateral occipital sulcus, being considered to be V5/MT area. This was the first reort to identify V5/MT in humans. Less

为了探讨人类大脑在时间和空间信息方面的感觉知觉机制，我们研究了电刺激或机械刺激头皮、嘴唇、上肢和下肢后的磁诱发场（SEF），证实了Penfield博士报道的初级感觉区（SI）内的“侏儒”现象。一般来说，感受野与“侏儒”一致，但个体间差异很大，特别是在SI的下肢区域。我们还发现了个体内（左-右）的差异。我们制作了一种新的装置来产生“被动运动”，以研究皮层对通过肌肉传入上行的信号的活动。手指被动运动后的波形和激活区域与施加到手指的电刺激或机械刺激后的波形和激活区域均显着不同。差异可能是由于面部 ...更多信息 采用图形反转黑、白色棋盘格刺激法记录VEF，主要研究初级视皮层（VI）对不同视野刺激的激活区。首先，我们使用半场和四分之一场刺激，并证实视网膜病变对应于激活区的分离在VI。这一发现是符合所谓的“十字形模型”。接下来，我们记录了中央和外周场刺激后的VEF。VEF对中央野的刺激主要位于枕叶冠部。维也纳环境论坛很难记录这些领域的活动。相反，外周场刺激的VEF以大幅度清晰地记录。记录到视向运动的VEF，发现颞下沟升分支与枕外侧沟交叉点附近有活动，认为是V5/MT区。这是第一个在人类中鉴定V5/MT的报告。少

项目成果

Kakigi R et al: "Effects of movement and movement imagery on somatosensory evoked magnetic fileds following posterior tibial nerve stimulation." Cognitive Brain Research. 5(3). 241-253 (1997)

Kakigi R 等人：“运动和运动意象对胫后神经刺激后体感诱发磁场的影响。”

Nakamura A, Kakigi R et al: "Visual evoked cortical magnetic fields to pattern reversal stimulation." Cognitive Brain Research. 6(1). 9-22 (1997)

Nakamura A、Kakigi R 等人：“视觉诱发皮层磁场以产生模式逆转刺激。”

Kakigi Ryusuke: "Pain-related magnetic fields foloowing painful CO2 laser stimulation in man." Neuroscience Letters. 192. 45-48 (1995)

Kakigi Ryusuke：“人体受到 CO2 激光刺激后会产生与疼痛相关的磁场。”

Sakuma K, Kakigi Ret al: "Odorant evoked magnetic fields in humans" Neurosciecne Research. 27(2). 115-122 (1997)

Sakuma K、Kakigi Ret al：“气味在人体中诱发磁场”神经科学研究。

Shimojo, M., Kakigi, R., et al.: "Magnetoencephalographic study of intracerebral interactions caused by bilateral posteior tibial nerve stimulation in man." Neurosci Res. 28. 41-47 (1997)

Shimojo, M.、Kakigi, R. 等人：“人类双侧后胫神经刺激引起的脑内相互作用的脑磁图研究”。