NON-INVASIVE STUDY OF HUMAN BRAIN FUNCTION USING PHYSIOLOGICAL METHODS,MAGNETOENCEPHALOGRAPHY AND ELECTROENCEPHALOGRAPHY

利用生理学方法、脑磁图和脑电图对人脑功能进行非侵入性研究

• 批准号: 07458215
• 负责人: KAKIGI Ryusuke
• 金额: $ 4.86万
• 依托单位: OKAZAKI NATIONAL RESEARCH INSTITUTES
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07458215/
• 关键词: Electroencephalography; Magnetoencehalography; Somatosensory sensation; Visual sensation; Apparent motion; Brain function; 仮現運動; ヒト; 高次脳機能; 痛覚; 双極子; 非侵襲; 温度覚; 神経生理学; 誘発電位

We studied magnetic evoked fields (EF) following somatosensory (SEF) and visual (VEF) stimulation to investigate the mechanisms of sensory perception in terms of temporal and spatial information in the human brain.SEFWe recorded SEF following electrical or mechanical stimulation applied to the scalp, lip, upper limb and lower limb, and reconfirmed "homunculus" in the primary sensory area (SI) reported by Dr. Penfield. In general, receptive fields are consistent with "homunculus", but a large inter-individual difference was found, particularly in the lower limb area in SI.We also found the intra-individual (left-right) difference. We made a new device to produce "passive movement" to investigate cortical activities to the signals ascending through muscle afferent. Both waveforms and activated areas following passive movement of fingers were significantly different from those following electrical or mechanical stimulation applied to the fingers. Probably the difference was due to the fac … More ts that are 3a in SI was activated follwoing a passive movement, but area 3b in SI was activated following electrical or mechanical stimulation.VEFWe used pattern-reversal black and white checker board stimulation to record VEF,mainly to investigate the activated areas in the primary visual cortex (VI) to various visual fields stimulation. At first, we used a half and quadrant field stimulation and confirmed that the retinotopy corresponded to the separation of activated areas in VI.This finding was consistent with a so-called "cruciform model". Next, we recorded VEF following central and peripheral field stimulation. VEF to the central field stimulation was mainly located in the crown of the occipital lobe. It is difficult for VEF to record activities in such areas. In contrast, VEF to the peripheral field stimulation was clearly recorded with a large amplitude. We recorded VEF to the aparent motion, and found activities around the crossing point of the ascending branch of the inferior temporal sulcul and lateral occipital sulcus, being considered to be V5/MT area. This was the first reort to identify V5/MT in humans. Less

本文研究了体感和视觉刺激后的磁诱发场（EF），探讨了人的感官知觉在时间和空间信息方面的机制。我们记录了对头皮、嘴唇、上肢和下肢进行电刺激或机械刺激后的SEF，并再次确认了Penfield博士报告的初级感觉区（SI）的“小样”。一般来说，感受野与“侏儒”一致，但个体间差异很大，特别是在SI的下肢区域。我们还发现了个体内部（左右）的差异。我们制作了一种新的装置来产生“被动运动”，以研究皮层对通过肌肉传入的信号的活动。手指被动运动后的波形和激活区域与对手指进行电刺激或机械刺激后的波形和激活区域有显著不同。在被动运动后，更多的3a区被激活，但在电刺激或机械刺激后，3b区被激活。我们采用黑白棋盘模式反转刺激法记录VEF，主要研究初级视觉皮层（VI）在不同视野刺激下的激活区域。首先，我们采用半场和四象限场刺激，证实视网膜切除对应于vi激活区的分离，这一发现与所谓的“十字形模型”一致。接下来，我们记录中央和外周野刺激后的VEF。中央野刺激的VEF主要位于枕叶冠部。环境基金很难记录这些领域的活动。外周场刺激下VEF明显，振幅较大。我们记录VEF到视运动，发现在颞下沟上升支与枕外侧沟交点附近有活动，认为是V5/MT区。这是首次在人类中发现V5/MT的报告。少

项目成果

Kakigi R et al: "Effects of movement and movement imagery on somatosensory evoked magnetic fileds following posterior tibial nerve stimulation." Cognitive Brain Research. 5(3). 241-253 (1997)

Kakigi R 等人：“运动和运动意象对胫后神经刺激后体感诱发磁场的影响。”

Nakamura A, Kakigi R et al: "Visual evoked cortical magnetic fields to pattern reversal stimulation." Cognitive Brain Research. 6(1). 9-22 (1997)

Nakamura A、Kakigi R 等人：“视觉诱发皮层磁场以产生模式逆转刺激。”

Kakigi Ryusuke: "Pain-related magnetic fields foloowing painful CO2 laser stimulation in man." Neuroscience Letters. 192. 45-48 (1995)

Kakigi Ryusuke：“人体受到 CO2 激光刺激后会产生与疼痛相关的磁场。”

Sakuma K, Kakigi Ret al: "Odorant evoked magnetic fields in humans" Neurosciecne Research. 27(2). 115-122 (1997)

Sakuma K、Kakigi Ret al：“气味在人体中诱发磁场”神经科学研究。

Shimojo, M., Kakigi, R., et al.: "Magnetoencephalographic study of intracerebral interactions caused by bilateral posteior tibial nerve stimulation in man." Neurosci Res. 28. 41-47 (1997)

Shimojo, M.、Kakigi, R. 等人：“人类双侧后胫神经刺激引起的脑内相互作用的脑磁图研究”。