CD4 T cell programming by neonatal and early-life infection

新生儿和生命早期感染导致的 CD4 T 细胞编程

• 批准号: DP0559210
• 负责人: Prof Paul Foster
• 金额: $ 17.34万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-23 至 2008-04-11
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0559210
• 关键词: CD4; cell; programming; neonatal; early

T lymphocytes (T cells) are white blood cells that play a critical role in protecting the body from infection. Before T cells can function they need to be programmed so that they can specifically respond to an infectious agent (a type of bacteria or virus). Inappropriate programming can lead to disease. Whether T cells respond to an infectious agent or foreign substance in a protective or destructive manner may critically depend on the age that an individual first encounters the infection. Our project will identify critical periods in life that direct T cell programming to subsequent protective or destructive responses, providing new insights into the developing immune system that may be exploited to treat disease or develop vaccines.

T淋巴细胞（T细胞）是白色血细胞，在保护身体免受感染方面起着关键作用。在T细胞发挥功能之前，它们需要被编程，以便它们能够特异性地对感染因子（一种细菌或病毒）做出反应。不适当的编程可能导致疾病。T细胞是否以保护性或破坏性的方式对感染因子或外来物质作出反应，可能关键取决于个体首次遇到感染的年龄。我们的项目将确定生命中的关键时期，指导T细胞编程随后的保护性或破坏性反应，为可能用于治疗疾病或开发疫苗的免疫系统的发展提供新的见解。