Phenotypic and functional characterisation of CD4 T helper 22 cells and their role in the regulation of chronic allergic disease of the lung and skin

CD4 T辅助细胞22的表型和功能特征及其在肺和皮肤慢性过敏性疾病调节中的作用

• 批准号: nhmrc : 1061413
• 负责人: Prof Paul Foster
• 金额: $ 47.61万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phenotypic-functional-characterisation-lung-skin/454894
• 关键词: Phenotypic; functional; characterisation; CD4; helper

Allergic inflammatory diseases such as asthma and allergic dermatitis are major health problems in our community that lead to poor quality of life. These diseases are induced by activation of immune cells known as T helper (Th) lymphocytes. Recently Th22 cells have been identified in patients with allergic diseases. In this study we will, for the first time, characterise these cells and determine their role in the processes that lead to chronic inflammation in asthma and allergic dermatitis.

过敏性炎症性疾病，如哮喘和过敏性皮炎，是我们社区的主要健康问题，导致生活质量下降。这些疾病是由称为辅助性T淋巴细胞的免疫细胞激活引起的。最近在过敏性疾病患者中发现了Th22细胞。在这项研究中，我们将首次描述这些细胞的特征，并确定它们在导致哮喘和过敏性皮炎慢性炎症的过程中的作用。