Phenotypic and functional characterisation of CD4 T helper 22 cells and their role in the regulation of chronic allergic disease of the lung and skin

过敏性炎症性疾病，如哮喘和过敏性皮炎，是我们社区的主要健康问题，导致生活质量下降。这些疾病是由被称为T辅助(Th)淋巴细胞的免疫细胞激活引起的。最近，在变态反应性疾病患者中发现了Th22细胞。在这项研究中，我们将首次确定这些细胞的特征，并确定它们在导致哮喘和过敏性皮炎的慢性炎症过程中的作用。

Allergic inflammatory diseases such as asthma and allergic dermatitis are major health problems in our community that lead to poor quality of life. These diseases are induced by activation of immune cells known as T helper (Th) lymphocytes. Recently Th22 cells have been identified in patients with allergic diseases. In this study we will, for the first time, characterise these cells and determine their role in the processes that lead to chronic inflammation in asthma and allergic dermatitis.