Understanding the role of Th22 cells in regulating respiratory immune responses in health and disease.

了解 Th22 细胞在调节健康和疾病中呼吸道免疫反应中的作用。

• 批准号: nhmrc : 1120448
• 负责人: Prof Paul Foster
• 金额: $ 59.57万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-th22-health-disease/946534
• 关键词: Understanding; role; Th22; cells; regulating

T cells that produce the cytokine IL-22 (Th22 cells) are found in infectious and inflammatory lung disease. However, the role of Th22 cells in promoting or preventing disease remains largely unknown. We have discovered how to grow Th22 cells and have generated a unique strain of IL-22 reporter mice, which will allow us to identify their role in infectious and inflammatory diseases. Our investigations will provide new insights into therapeutic approaches for these diseases of the lung.

产生细胞因子IL-22（Th 22细胞）的T细胞存在于感染性和炎性肺病中。然而，Th 22细胞在促进或预防疾病中的作用在很大程度上仍然未知。我们已经发现了如何培养Th 22细胞，并产生了一种独特的IL-22报告小鼠，这将使我们能够确定它们在感染性和炎症性疾病中的作用。我们的研究将为这些肺部疾病的治疗方法提供新的见解。