Characterising the pro-inflammatory role of IL-36?/IL-36R in pathogen-induced exacerbations of asthma and COPD

肺部感染导致哮喘和COPD患者病情加重，这些疾病难以治疗，可能危及生命。我们已经发现，细胞因子途径，IL-36？/ IL-36 R与宿主对细菌和病毒感染的反应有关，这些感染诱导这些患者的病情加重。我们的研究将为IL-36？/ IL-36 R在感染、疾病恶化中的作用，并确定阻断该途径的治疗益处。

Lung infections cause exacerbations in patients with asthma and COPD and these are difficult to treat and can be life-threatening. We have discovered that the cytokine pathway, IL-36?/IL-36R, is linked to the host response to bacterial and viral infections that induce exacerbations in these patients. Our studies will provide new insight into the role IL-36?/IL-36R in infection, disease exacerbation and determine the therapeutic benefit of blocking this pathway.