Characterising the pro-inflammatory role of IL-36?/IL-36R in pathogen-induced exacerbations of asthma and COPD

表征 IL-36?/IL-36R 在病原体诱导的哮喘和 COPD 恶化中的促炎作用

• 批准号: nhmrc : 1120237
• 负责人: Prof Paul Foster
• 金额: $ 50.49万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterising-pro-inflammatory-asthma-copd/946465
• 关键词: Characterising; pro; inflammatory; role; IL

Lung infections cause exacerbations in patients with asthma and COPD and these are difficult to treat and can be life-threatening. We have discovered that the cytokine pathway, IL-36?/IL-36R, is linked to the host response to bacterial and viral infections that induce exacerbations in these patients. Our studies will provide new insight into the role IL-36?/IL-36R in infection, disease exacerbation and determine the therapeutic benefit of blocking this pathway.

肺部感染导致哮喘和COPD患者病情加重，这些疾病难以治疗，可能危及生命。我们已经发现，细胞因子途径，IL-36？/ IL-36 R与宿主对细菌和病毒感染的反应有关，这些感染诱导这些患者的病情加重。我们的研究将为IL-36？/ IL-36 R在感染、疾病恶化中的作用，并确定阻断该途径的治疗益处。