Influence of early-life viral infection on severity of murine chronic asthma and acute exacerbations

生命早期病毒感染对小鼠慢性哮喘和急性加重严重程度的影响

• 批准号: nhmrc : 455223
• 负责人: Prof Paul Foster
• 金额: $ 33.91万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/influence-early-life-acute-exacerbations/83184
• 关键词: Influence; early; life; viral; infection

This project examines the relationship between certain childhood infections with respiratory viruses and the progression of asthma later in life. The experimental work will use mouse models of mild chronic asthma and of an acute exacerbation of the illness -- these unique models have been developed in the laboratories of the chief investigators. It will employ the most appropriate mouse models of infection by the relevant group of viruses. We expect to obtain new information about mechanisms of airway inflammation and airway hyper-reactivity, which are characteristic features of chronic asthma and of acute exacerbations. This could help to identify candidate signalling molecules and pathways that could be targeted by new treatments. The findings might also provide a basis for development of ways to modify the immune response after respiratory viral infection in childhood.

该项目研究了某些儿童呼吸道病毒感染与以后生活中哮喘进展之间的关系。实验工作将使用轻度慢性哮喘和疾病急性加重的小鼠模型-这些独特的模型已在首席研究员的实验室中开发。它将采用最合适的小鼠模型感染相关组的病毒。我们期望获得有关气道炎症和气道高反应性机制的新信息，这是慢性哮喘和急性发作的特征。这可能有助于确定候选信号分子和途径，这些分子和途径可以被新的治疗方法所靶向。这一发现也可能为开发改变儿童呼吸道病毒感染后免疫反应的方法提供基础。