Targeting translational control by modulating miRNA function as a novel way to treat respiratory infections and inflammatory disease

通过调节 miRNA 功能来靶向翻译控制作为治疗呼吸道感染和炎症性疾病的新方法

• 批准号: nhmrc : 1062278
• 负责人: Prof Paul Foster
• 金额: $ 46.72万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-translational-control-inflammatory-disease/454976
• 关键词: Targeting; translational; control; modulating; miRNA

Among the major health issues of today is our inability to effectively treat bacterial infections and the emergence of antibiotic resistant microbes. MicroRNA are small molecules that control the levels of proteins in immune cells that fight infections. In this project we will determine if inhibiting miRNA function in the lung enhances defence against microbial invasion and is a new therapeutic approach to treat infection driven diseases of the airways such asthma and emphysema.

当今的主要健康问题之一是我们无法有效地治疗细菌感染和抗生素耐药性微生物的出现。MicroRNA是一种小分子，可以控制免疫细胞中对抗感染的蛋白质水平。在本项目中，我们将确定抑制肺部的miRNA功能是否可以增强对微生物入侵的防御，并且是治疗哮喘和肺气肿等感染驱动的气道疾病的新治疗方法。