Nascent chain biology

点击翻译按钮获取中文摘要

We develop a new area of research, which might be called“nascent chain biology” by addressing a concept that translation elongation speed isfine-tuned by the amino acid sequences of the nascent polypeptide as well as bydynamic behaviors of the extra-ribosomal portion of the same nascent chain. Weidentified regulatory nascent polypeptides such as SecM and MifM that function inaccordance with this principle and studied molecular mechanisms and physiologicaloutcomes of the regulation. Also, we have developed an experimental method thatenables us to display cellular polypeptidyl-tRNAs, obligatory but poorly studiedintermediates in translation, which we have proposed to call "nascentome".