A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization

在恶性实体癌中，手术和放射治疗后癌细胞的增殖有时会加速，癌症可能会在短期内复发。人们认为肿瘤干细胞的耐药性和高的血管诱导性带来了肿瘤组织的快速扩张，但目前还没有找到控制的方法。根据作者过去对肥大细胞肿瘤的研究，我们评估了抑制血管生成的内源性抑制药和控制新生血管的缺氧诱导因子的沉默疗法或基因控制疗法。我们开发了有效的治疗方法来控制新生血管。此外，我们还阐明了肿瘤干细胞耐药的机制，为建立新的治疗方法提供了基础研究数据。

In a malignant solid carcinoma, proliferation of cancer cells are sometimes accelerated after a surgery and radiation therapy and a cancer may recur in a short term. It is thought that a cancer stem cell of the drug resistance and the high vascularization inducibility bring the rapid expansion of the cancer tissue, but the control method is not yet found. Based on the author's past research on mast cell tumors, we evaluated a silencing therapy or a gene control therapy for the endogenous inhibitors for vascularization and hypoxia inducible factors which controlled neo-vascularization. We developed effective therapy for controlling neo-vascularization. In addition, we elucidated mechanism of the drug resistance of cancer stem cells and obtained fundamental researche data for establishment of a novel therapy.