A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization

在恶性实体癌中，在手术和放射治疗后，癌细胞的增殖有时会加速，并且癌症可能在短期内复发。人们认为是一种具有耐药性和高血管化诱导能力的癌症干细胞导致了癌组织的快速扩张，但目前还没有找到控制方法。结合笔者以往对肥大细胞肿瘤的研究，我们对内源性血管形成抑制剂和控制新生血管形成的缺氧诱导因子进行了沉默治疗或基因控制治疗。我们开发了有效的治疗方法来控制新血管形成。此外，我们还阐明了肿瘤干细胞的耐药机制，为建立新的治疗方法获得了基础研究数据。

In a malignant solid carcinoma, proliferation of cancer cells are sometimes accelerated after a surgery and radiation therapy and a cancer may recur in a short term. It is thought that a cancer stem cell of the drug resistance and the high vascularization inducibility bring the rapid expansion of the cancer tissue, but the control method is not yet found. Based on the author's past research on mast cell tumors, we evaluated a silencing therapy or a gene control therapy for the endogenous inhibitors for vascularization and hypoxia inducible factors which controlled neo-vascularization. We developed effective therapy for controlling neo-vascularization. In addition, we elucidated mechanism of the drug resistance of cancer stem cells and obtained fundamental researche data for establishment of a novel therapy.