A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization

实体瘤增殖抑制方案调节癌症干细胞和新生血管的研究

• 批准号: 20248032
• 负责人: MATSUDA Hiroshi
• 金额: $ 28.29万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20248032/
• 关键词: 低酸素反応性因子; 癌; 遺伝子治療; 治療

In a malignant solid carcinoma, proliferation of cancer cells are sometimes accelerated after a surgery and radiation therapy and a cancer may recur in a short term. It is thought that a cancer stem cell of the drug resistance and the high vascularization inducibility bring the rapid expansion of the cancer tissue, but the control method is not yet found. Based on the author's past research on mast cell tumors, we evaluated a silencing therapy or a gene control therapy for the endogenous inhibitors for vascularization and hypoxia inducible factors which controlled neo-vascularization. We developed effective therapy for controlling neo-vascularization. In addition, we elucidated mechanism of the drug resistance of cancer stem cells and obtained fundamental researche data for establishment of a novel therapy.

在恶性实体癌中，在手术和放射治疗后，癌细胞的增殖有时会加速，并且癌症可能在短期内复发。肿瘤组织的迅速扩张被认为是肿瘤干细胞的耐药性和高血管化诱导因子引起的，但目前还没有找到控制方法，基于作者过去对肥大细胞肿瘤的研究，我们对控制新生血管形成的内源性血管化抑制因子和缺氧诱导因子进行沉默治疗或基因控制治疗。我们开发了有效的治疗方法来控制新血管形成。此外，我们还阐明了肿瘤干细胞耐药的机制，为建立新的治疗方法提供了基础研究数据。

项目成果

ヒト中皮腫細胞における腫瘍性増殖制御分子としての転写因子NF-κBの役割

转录因子 NF-κB 作为人间皮瘤细胞肿瘤生长控制分子的作用

• 发表时间: 2010
• 作者: Nishikawa S;Tanaka A;Ohm・ri K;MatsudaH
• 通讯作者: MatsudaH

Inhibition of nuclear factor-KQ activity restored glucocarticoid sensitivity in lymphocytes and mast cells.

抑制核因子-KQ 活性可恢复淋巴细胞和肥大细胞中的糖皮质激素敏感性。

• 发表时间: 2010
• 作者: Matsuda A;Tanaka A;Ohmori K;Matsuda H.
• 通讯作者: Matsuda H.

Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus

超纯软水洗发水治疗犬瘙痒症的效果中试评价

• DOI: 10.1111/j.1365-3164.2010.00900.x
• 发表时间: 2010
• 期刊: Vet Dermatol
• 影响因子: 1.4
• 作者: Ohmori K;Tanaka A;Makita Y;Takai M;Yoshinari;Y;Matsuda H.
• 通讯作者: Matsuda H.

A novel NF-κB inhibitor improves glucocorticoid sensitivity of canine neoplastic lymphoid cells by up-regulating expression of glucocorticoid receptors

• DOI: 10.1016/j.rvsc.2010.03.017
• 发表时间: 2010-12-01
• 期刊: RESEARCH IN VETERINARY SCIENCE
• 影响因子: 2.4
• 作者: Matsuda, A.;Tanaka, A.;Matsuda, H.
• 通讯作者: Matsuda, H.

Update・f NC/NgaTnd mice as an atopic dermatitis model.

更新・f NC/NgaTnd 小鼠作为特应性皮炎模型。

• 发表时间: 2009
• 作者: Ikushima M;Ishii M;Ohishi M;Yamamoto K;Ogihara T;Rakugi H;Kurachi Y.;Hir・shi Matsuda
• 通讯作者: Hir・shi Matsuda