A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization
A study on the suppression protocol on proliferation of solid tumors regulating cancer stem cells and neo-vascularization
批准号:
20248032
负责人:
MATSUDA Hiroshi
金额:
$28.29万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In a malignant solid carcinoma, proliferation of cancer cells are sometimes accelerated after a surgery and radiation therapy and a cancer may recur in a short term. It is thought that a cancer stem cell of the drug resistance and the high vascularization inducibility bring the rapid expansion of the cancer tissue, but the control method is not yet found. Based on the author's past research on mast cell tumors, we evaluated a silencing therapy or a gene control therapy for the endogenous inhibitors for vascularization and hypoxia inducible factors which controlled neo-vascularization. We developed effective therapy for controlling neo-vascularization. In addition, we elucidated mechanism of the drug resistance of cancer stem cells and obtained fundamental researche data for establishment of a novel therapy.
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ヒト中皮腫細胞における腫瘍性増殖制御分子としての転写因子NF-κBの役割
转录因子 NF-κB 作为人间皮瘤细胞肿瘤生长控制分子的作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Nishikawa S, Tanaka A, Ohm・ri K, MatsudaH]
通讯作者:
MatsudaH
Inhibition of nuclear factor-KQ activity restored glucocarticoid sensitivity in lymphocytes and mast cells.
抑制核因子-KQ 活性可恢复淋巴细胞和肥大细胞中的糖皮质激素敏感性。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Matsuda A, Tanaka A, Ohmori K, Matsuda H.]
通讯作者:
Matsuda H.
DOI:
10.1016/j.rvsc.2010.03.017
发表时间:
2010-12-01
期刊:
RESEARCH IN VETERINARY SCIENCE
影响因子:
2.4
作者:
[Matsuda, A., Tanaka, A., Matsuda, H.]
通讯作者:
Matsuda, H.
Pilot evaluation of the efficacy of shampoo treatment with ultra-pure soft water for canine pruritus
超纯软水洗发水治疗犬瘙痒症的效果中试评价
DOI:
10.1111/j.1365-3164.2010.00900.x
发表时间:
2010
期刊:
Vet Dermatol
影响因子:
1.4
作者:
[Ohmori K, Tanaka A, Makita Y, Takai M, Yoshinari, Y, Matsuda H.]
通讯作者:
Matsuda H.
Update・f NC/NgaTnd mice as an atopic dermatitis model.
更新・f NC/NgaTnd 小鼠作为特应性皮炎模型。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ikushima M, Ishii M, Ohishi M, Yamamoto K, Ogihara T, Rakugi H, Kurachi Y., Hir・shi Matsuda]
通讯作者:
Hir・shi Matsuda
共 30 条
Evaluation index of ride comfort and fatigue for drivers and occupants by vehicle vibration
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批准号:19K04739
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.5万
-
财政年份:2019
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负责人:MATSUDA Hiroshi
-
依托单位:
Development of an efficient and low cost diagnostic method for soundness of bridges by optical measurement method without temporary scaffolding
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批准号:17H03298
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
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财政年份:2017
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负责人:MATSUDA Hiroshi
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依托单位:
Redefinition of intractable inflammatory diseases based on mast cell activation syndrome
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批准号:16H06383
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$120.56万
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财政年份:2016
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负责人:MATSUDA Hiroshi
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依托单位:
Effect of sound on vibration sensation for horizontal vibration generated in vehicle and amusement facility
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批准号:16K06622
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2016
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负责人:MATSUDA Hiroshi
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依托单位:
Development of low-cost inspection system by the optical method of bridge over the sea
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批准号:26630214
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2014
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负责人:MATSUDA Hiroshi
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依托单位:
Investigation of effect and evaluating method of fluctuating low frequency sound on efficiency of mental task
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批准号:25420615
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2013
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负责人:MATSUDA Hiroshi
-
依托单位:
A molecular study on skin barrier dysfunction in atopic dermatitis
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批准号:24248055
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$20.72万
-
财政年份:2012
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负责人:MATSUDA Hiroshi
-
依托单位:
A patho-physiological study on perinatal abnormalities in NC/Tnd mice
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批准号:24658267
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.58万
-
财政年份:2012
-
负责人:MATSUDA Hiroshi
-
依托单位:
Studies on the evaluation method of deterioration and health in the micro-meso-macro level of infrastructure by optical measurement technology
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批准号:24360182
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.98万
-
财政年份:2012
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负责人:MATSUDA Hiroshi
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依托单位:
Quantitative evaluation of self-restration capacity of granulated blast furnace slag
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批准号:23560993
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:MATSUDA Hiroshi
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依托单位:
A study on knots and transverse knots using braid theory and Floer theory
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批准号:23740053
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2011
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负责人:MATSUDA Hiroshi
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依托单位:
Development of real-time non-contact vibration measurement by optical methods and application to nondestructive testing
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批准号:21360217
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2009
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负责人:MATSUDA Hiroshi
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依托单位:
CONTROL OF CUTTER MARKS ARRAY BY SIMULTANEOUS MULTI-AXIS CONTROLLED MILLING USING BALL-END MILL
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批准号:21760105
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$3.0万
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财政年份:2009
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负责人:MATSUDA Hiroshi
-
依托单位:
Establishment of a novel method for imaging diagnosis of Alzheimer's disease
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批准号:21591578
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.5万
-
财政年份:2009
-
负责人:MATSUDA Hiroshi
-
依托单位:
A study on knots using braid theory and Heegaard Floer theory
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批准号:20740041
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2008
-
负责人:MATSUDA Hiroshi
-
依托单位:
Development of multi-scale structural damage identification by utilizing full-field optical sensing techniques
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批准号:19360205
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$13.06万
-
财政年份:2007
-
负责人:MATSUDA Hiroshi
-
依托单位:
Establishment of statistical image analysis for diagnosis of very early Alzheimer's disease
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批准号:18591364
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2006
-
负责人:MATSUDA Hiroshi
-
依托单位:
An exhaustive study of tumorigenesis and development of a novel molecular targeting therapy for canine mastocytoma
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批准号:17208027
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.45万
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财政年份:2005
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负责人:MATSUDA Hiroshi
-
依托单位:
Elucidation of deteriorative mechanism of construction structures and development of diagnostic method by optic full-field measurement techniques
-
批准号:17360217
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.3万
-
财政年份:2005
-
负责人:MATSUDA Hiroshi
-
依托单位:
Design for earthquake-resistant earth structures using the latent hydraulic property of granulated blast furnace slag
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批准号:16560714
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.37万
-
财政年份:2004
-
负责人:MATSUDA Hiroshi
-
依托单位:
国内基金
海外基金
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