A patho-physiological study on perinatal abnormalities in NC/Tnd mice

NC/Tnd 小鼠围产期异常的病理生理学研究

• 批准号: 24658267
• 负责人: MATSUDA Hiroshi
• 金额: $ 2.58万
• 依托单位: Tokyo University of Agriculture and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24658267/
• 关键词: 臨床病理・病態; 羊水塞栓症; 動物モデル; トランスレーショナルリサーチ; 疾患モデル動物; 病理学; 動物

NC/Tnd mice are widely used for a study on atopic dermatitis as a spontaneous model all over the world, but breeding is difficult and there are some maternal death in the third pregnancy trimester and newborn baby death at the time of the delivery. However, the cause has been unclear. The amniotic fluid embolism which has a serious influence on a perinatal mother's body brings the anaphylactic condition of a patient. Therefore, in this study, we focused on perinatal abnormality occurred in NC/Tnd mice and examined immune status of the mice during pregnancy. As a result, the blood concentration of anaphylatoxin and the platelet activating factor was higher than the standard mice. Results indicate that the Th1 immune responses in pregnant NC/Tnd mice may involve in abnormalities that are noticed during the perinatal period.

NC/TND小鼠作为一种自发的特应性皮炎模型在世界各地被广泛用于研究，但饲养困难，在妊娠晚期有母体死亡，分娩时有新生儿死亡。然而，原因尚不清楚。羊水栓塞对围产期母亲的身体有严重的影响，导致患者的过敏状态。因此，本研究以NC/TND小鼠发生的围产期异常为研究对象，对其孕期免疫状态进行检测。结果表明，小鼠血中过敏性毒素和血小板活化因子浓度均高于正常小鼠。结果表明，妊娠NC/TND小鼠Th1免疫反应可能与围产期异常有关。

项目成果

アトピー性皮膚炎に対する知覚神経刺激への応答性とTRPV1の関連性の検討

特应性皮炎中感觉神经刺激反应性与 TRPV1 关系的研究

• 作者: 夏彦;田中あかね;大森啓太郎;松田浩珍
• 通讯作者: 松田浩珍

Abnormalities in Itch Sensation and Skin Barrier Function in Atopic NC/Tnd Mice

• DOI: 10.1248/bpb.b13-00333
• 发表时间: 2013-08-01
• 期刊: BIOLOGICAL & PHARMACEUTICAL BULLETIN
• 影响因子: 2
• 作者: Amagai, Yosuke;Matsuda, Hiroshi;Tanaka, Akane
• 通讯作者: Tanaka, Akane

The benefits of comaparative approaches for atopic dermatitis

特应性皮炎比较方法的好处

• 发表时间: 2012
• 作者: 張孝善、松田浩珍;他;松田浩珍
• 通讯作者: 松田浩珍

アトピー性皮膚炎モデルマウスにおける皮膚pHと皮膚バリア損傷の関連性

特应性皮炎模型小鼠皮肤pH值与皮肤屏障损伤的关系

• 发表时间: 2012
• 作者: 張孝善、松田浩珍;他
• 通讯作者: 他

Recent findings in mouse models for human atopic dermatitis

人类特应性皮炎小鼠模型的最新发现

• 发表时间: 2012
• 期刊: Exp Anim
• 作者: Tanaka A;Amagai Y;Oida K;Matsuda H
• 通讯作者: Matsuda H