Role of diseased angiogenesis in diabetic cardiomyopathy and its significance for the invention of novel therapeutic strategy.

心肌细胞生长和冠状动脉血管生成减少之间的不匹配促进适应不良的心脏重塑，包括糖尿病心肌病。糖尿病增强心脏氨肽酶活性，促进血管生成趋化因子SDF 1-α的降解，导致冠状动脉血管生成减少和心脏重塑。我们的数据表明，心脏氨基肽酶活性的调节可能是糖尿病适应不良心脏重构的治疗策略所必需的。

Mismatch between cardiomyocyte growth and reduced coronary angiogenesis promotes maladaptive cardiac remodeling including diabetic cardiomyopathy. Diabetes enhances cardiac aminopeptidase activity which promotes degradation in angiogenic chemokine SDF1-α, leading to reduced coronary angiogenesis and resultant cardiac remodeling. Our data suggest that regulation of cardiac aminopepetidase activity may be essential for therapeutic strategy of maladaptive cardiac remodeling in diabetes.