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Development of non-invasive measurement of blood constituents using ultra-high speed differential near-infrared spectrophotometry

开发利用超高速差示近红外分光光度法对血液成分进行无创测量的技术

基本信息

批准号：
21240047
负责人：
YAMAKOSHI Ken-ichi
金额：
$ 27.96万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2009
资助国家：
日本
起止时间：
2009 至 2012
项目状态：
已结题

项目摘要

The final goal of this research project is to establish non-invasive blood constituents measurement towards practical use based on the ultra-high speed differential near-infrared spectrophotometry using arterial volume signals detected photoelectrically (photoplethysmogram; PPG).To achieve this goal, absorption spectra of sampled blood have been accurately examined in vitro with a wavelength range of 900 - 2500 nm, determining the sensitivity ratio which represents the absorption change with respect to the change in concentration of solutions of such substances as glucose, human serum albumin and ethyl alcohol in specified wavelength bands. Based on these in vitro tests and a background of practical needs to obtain blood glucose (BGL) and alcohol (BAL) concentrations, we have tried to make in vivo experiments under theoretical investigations with the modified Beer-Lambert la w, showing relatively good results to predict BGL and BAL concentrations (named as pulse glucometry and pulse alcometry). In order to obtain more accurate predictions, we have also proposed a new PPG measurement technique using an integrating sphere with high optical sensitivity as well as high S/N of PPG signals, serving as a principal foundation for practical use.

本研究的最终目的是建立一种基于超高速差分近红外光谱技术的无创血液成分检测方法，并将其应用于临床（光电容积描记图;为了实现这一目标，已经在体外用900 - 2500 nm的波长范围准确地检查了采样血液的吸收光谱，测定灵敏度比，该灵敏度比表示葡萄糖、人血清白蛋白、乙醇等物质溶液在特定波段的吸收变化相对于浓度变化的变化。在此基础上，以实际需要测定血糖（BGL）和酒精（BAL）浓度为背景，尝试用改进的Beer-Lambert定律进行理论研究下的体内实验，得到了较好的预测BGL和BAL浓度的结果（称为脉冲葡萄糖浓度和脉冲酒精浓度）。为了获得更准确的预测，我们还提出了一种新的PPG测量技术，使用具有高光学灵敏度以及PPG信号的高S/N的积分球，作为实际使用的主要基础。

项目成果

期刊论文数量（32）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

非侵襲生体計測技術の新展開-超高齢社会とユビキタス・ヘルスケア-

无创生物测量技术新进展-超级老龄化社会与无处不在的医疗保健-

DOI：
发表时间：
2009
期刊：
影响因子：
0
作者：
Jung J.;Iijima M.;Yoshimoto N.;Sasaki M.;Niimi T.;Tatematsu K.;Jeong S.Y.;Choi E.K.;Tanizawa K.;and Kuroda S.;山越憲一
通讯作者：
山越憲一

Determination of concentrations of glucose and human serum albumin in mixtures in phosphate-buffered solution by nearinfrared spectroscopy

近红外光谱法测定磷酸盐缓冲溶液混合物中葡萄糖和人血清白蛋白的浓度