Development of Non-invasive and Ambulatory System for the Monitoring of Instantaneous Cardiovascular Hemodynamic Parameters along with Autonomic Activities

开发用于监测瞬时心血管血流动力学参数和自主活动的无创动态系统

基本信息

批准号：
14208105
负责人：
YAMAKOSHI Ken-ichi
金额：
$ 17.64万
依托单位：
Kanazawa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In order to assess on-line autonomic regulation of cardiovascular system during daily activities, a non-invasive and ambulatory system has been successfully developed, which can automatically monitor instantaneous digital or radial systolic (SBP), mean (MBP), and diastolic blood pressure (DBP), stroke volume (SV), heart rate (HR), cardiac output (CO=SV・HR), and total peripheral circulatory resistance (TPR=MBP/CO). Principle of the instantaneous blood pressure measurement is based on the volume-compensation method using the photoplethysmographic vascular unloading technique with a newly designed partially pressurization cuff, while that of the CO measurement based on the electrical admittance (or impedance) cardiography with newly proposed spot electrodes alignment.As to accuracy of the system, the performance of the instantaneous radial blood pressure measurement method was evaluated with the direct blood pressure measurement using 9 healthy subjects. The results of the Bland-Altman an … More alysis of the SBP and DBP measurements were -0.46±4.1 and 0.63±3.3mmHg (mean±1.96SD, (accuracy±precision)), respectively. The performances of the admittance cardiography with the spot electrodes (the current source electrode pair : behind of the ears-right side of the waist, the detection electrode pair : manubrium-xiphoid process (the both ends of the sternum)) were also evaluated with the dye-dilution cardiac output measurement. Appling to the Kubicek's method of the impedance (or admittance) cardiography, the assumption of the homogeneity of the current distribution of the thorax between these spat electrodes was confirmed by the 24 (4 x 6) spot electrodes thorax impedance mapping system. The result of the Bland-Altman analysis of the CO measurements was 0.2±2.0l/min (mean±1.96SD).Using this system, the autonomic regulation analysis was conducted by the spectral method of the FFT and MEM (Maximum Entropy Method). The high frequency component (HF : 0.15-0.5Hz) of the IBI (inter-beat interval) has been recognized as the index of the vagal nerve activity. The low frequency component (LF : 0.04-0.12Hz) of the TPR was proposed as the solely index of the sympathetic nerve activity. However, these indexes had been failed to describe sudden changes of the human activities due to long range of data requirements, i.e. 64-128 points. We concluded that further development of the instantaneous autonomic regulation analysis should be desired to evaluate in detail human activities against various stress conditions during daily life. Less

In order to assess on-line autonomic regulation of cardiovascular system during daily activities, a non-invasive and ambulatory system has been successfully developed, which can automatically monitor instantaneous digital or radial systolic (SBP), mean (MBP), and diastolic blood pressure (DBP), stroke volume (SV), heart rate (HR), cardiac output (CO=SV・HR), and total peripheral电路电阻（TPR = MBP/CO）。瞬时血压测量的原理基于使用的体积补偿方法，该方法使用新设计的部分压力袖带的光插图学血管卸载技术，而基于电力摄影（或障碍）的CO测量袖口的精确量置于置于血液的范围中，该方法的辐射是置换的。使用9个健康受试者进行测量。 Bland -Altman的结果……对SBP和DBP测量结果的更多分析分别为-0.46±4.1和0.63±3.3mmHg（平均值±1.96SD，（准确性±精度））。还通过染料 - 稀释性心脏输出测量值评估了使用点电子（当前电极对：在腰部的耳朵右侧，Manubrium-Xiphoid工艺（Manubrium-Xiphoid工艺））的表演（当前的电极对：在耳朵右侧的后面）。 24（4 x 6）胸腔阻抗映射系统证实了对库宾斯克的阻抗（或入院）心脏造影的方法的涂抹方法。 CO测量的平淡 - altman分析的结果为0.2±2.0L/min（平均值±1.96SD）。使用该系统，通过FFT和MEM（最大熵方法）进行了自主调节分析。 IBI的高频成分（HF：0.15-0.5Hz）（bi间间隔）已被认为是迷走神经活动的指数。提出了TPR的低频成分（LF：0.04-0.12Hz），是交感神经活动的唯一指数。但是，这些索引未能描述由于较长的数据要求，即64-128点而导致人类活动的突然变化。我们得出的结论是，应要求对瞬时自主法规分析的进一步发展进行详细评估人类活动，以应对日常生活中各种压力条件进行评估。较少的

项目成果

期刊论文数量（40）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

野川雅道, 田中志信, 高田重男, 根本鉄, 山越憲一: "無侵襲心拍出量計測法の改良と評価に関する研究"金沢大学大学院自然科学研究科システム創成科学専攻紀要. 3. 27-34 (2002)

野川正道、田中忍、高田茂夫、根本哲、山越健一：《无创心输出量测量方法的改进与评价研究》金泽大学自然科学技术研究科系统创造科学系通报3. 27-34 (2002)

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五十嵐朗, 佐々木圭, 諸江輝義, 野川雅道, 田中志信, 山越憲一: "電気的インピーダンス式心拍出量計測における最適電極配置と精度評価"第18回生体・生理工学シンポジウム論文集. 377-378 (2003)

Akira Igarashi、Kei Sasaki、Teruyoshi Moroe、Masamichi Nokawa、Shinobu Tanaka、Kenichi Yamakoshi：“电阻抗心输出量测量中的最佳电极放置和精度评估”第 18 届生物和生理工程研讨会论文集 377-378（2003 年）。

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K.Yamakoshi, M.Nogawa, S.Tanaka et al.: "A New Proposal of Optimal Spot-electrode Array for Electrical Impedance Cardiography Through the Measurement of Thoracic Impedance Mapping"IEEE Engineering in Medicine and Biology Society 25th Annual International

K.Yamakoshi、M.Nokawa、S.Tanaka 等人：“A New Proposal of Optimal Spot- Electrode Array for Electrical Impedance Cardiography Through theMeasurement of Thoracic Impedance Mapping”IEEE Engineering in Medicine and Biology Society 25th Annual International