Development of Non-invasive and Ambulatory System for the Monitoring of Instantaneous Cardiovascular Hemodynamic Parameters along with Autonomic Activities

开发用于监测瞬时心血管血流动力学参数和自主活动的无创动态系统

• 批准号: 14208105
• 负责人: YAMAKOSHI Ken-ichi
• 金额: $ 17.64万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14208105/
• 关键词: Non-invasive and ambulatory cardiovascular monitoring; Cardiovascular hemodynamic parameters; Autonomic regulation; Cardiovascular regulatory function; Instantaneous blood pressure; Volume-compensation method; Instantaneous cardiac output; Admittan

In order to assess on-line autonomic regulation of cardiovascular system during daily activities, a non-invasive and ambulatory system has been successfully developed, which can automatically monitor instantaneous digital or radial systolic (SBP), mean (MBP), and diastolic blood pressure (DBP), stroke volume (SV), heart rate (HR), cardiac output (CO=SV・HR), and total peripheral circulatory resistance (TPR=MBP/CO). Principle of the instantaneous blood pressure measurement is based on the volume-compensation method using the photoplethysmographic vascular unloading technique with a newly designed partially pressurization cuff, while that of the CO measurement based on the electrical admittance (or impedance) cardiography with newly proposed spot electrodes alignment.As to accuracy of the system, the performance of the instantaneous radial blood pressure measurement method was evaluated with the direct blood pressure measurement using 9 healthy subjects. The results of the Bland-Altman an … More alysis of the SBP and DBP measurements were -0.46±4.1 and 0.63±3.3mmHg (mean±1.96SD, (accuracy±precision)), respectively. The performances of the admittance cardiography with the spot electrodes (the current source electrode pair : behind of the ears-right side of the waist, the detection electrode pair : manubrium-xiphoid process (the both ends of the sternum)) were also evaluated with the dye-dilution cardiac output measurement. Appling to the Kubicek's method of the impedance (or admittance) cardiography, the assumption of the homogeneity of the current distribution of the thorax between these spat electrodes was confirmed by the 24 (4 x 6) spot electrodes thorax impedance mapping system. The result of the Bland-Altman analysis of the CO measurements was 0.2±2.0l/min (mean±1.96SD).Using this system, the autonomic regulation analysis was conducted by the spectral method of the FFT and MEM (Maximum Entropy Method). The high frequency component (HF : 0.15-0.5Hz) of the IBI (inter-beat interval) has been recognized as the index of the vagal nerve activity. The low frequency component (LF : 0.04-0.12Hz) of the TPR was proposed as the solely index of the sympathetic nerve activity. However, these indexes had been failed to describe sudden changes of the human activities due to long range of data requirements, i.e. 64-128 points. We concluded that further development of the instantaneous autonomic regulation analysis should be desired to evaluate in detail human activities against various stress conditions during daily life. Less

为了在线评估日常活动中心血管系统的自主调节情况，成功开发了一种非侵入式动态系统，可以自动监测瞬时数字或径向收缩压（SBP）、平均血压（MBP）和舒张压（DBP）、每搏输出量（SV）、心率（HR）、心输出量（CO=SV・HR）和总外周血。 循环阻力（TPR=MBP/CO）。瞬时血压测量原理是基于体积补偿方法，采用光电容积描记血管卸载技术，采用新设计的部分加压袖带，而CO测量原理是基于电导纳（或阻抗）心电图，采用新提出的点电极对准。对于系统的准确性，对瞬时径向血压测量方法的性能进行了评估 使用 9 名健康受试者进行直接血压测量。 Bland-Altman 对 SBP 和 DBP 测量值的分析结果分别为 -0.46±4.1 和 0.63±3.3mmHg（平均值±1.96SD，（准确度±精密度））。点电极（电流源电极对：耳后-腰部右侧，检测电极对：柄-剑突（胸骨两端））的导纳心电图的性能也通过染料稀释心输出量测量进行评估。应用阻抗（或导纳）心动图的 Kubicek 方法，24（4 x 6）点电极胸部阻抗绘图系统证实了这些胸腔电极之间胸部电流分布均匀性的假设。 CO测量的Bland-Altman分析结果为0.2±2.0l/min（平均值±1.96SD）。利用该系统，通过FFT和MEM（最大熵法）的谱法进行自主调节分析。 IBI（搏动间间隔）的高频成分（HF：0.15-0.5Hz）已被公认为迷走神经活动的指标。 TPR 的低频分量（LF：0.04-0.12Hz）被提议作为交感神经活动的唯一指标。但由于数据要求范围较长（64-128分），这些指标无法描述人类活动的突变。我们的结论是，应该进一步发展瞬时自主调节分析，以详细评估日常生活中各种压力条件下的人类活动。较少的

项目成果

野川雅道, 田中志信, 高田重男, 根本 鉄, 山越憲一: "無侵襲心拍出量計測法の改良と評価に関する研究"金沢大学大学院自然科学研究科 システム創成科学専攻紀要. 3. 27-34 (2002)

野川正道、田中忍、高田茂夫、根本哲、山越健一：《无创心输出量测量方法的改进与评价研究》金泽大学自然科学技术研究科系统创造科学系通报3. 27-34 (2002)

五十嵐朗, 佐々木圭, 諸江輝義, 野川雅道, 田中志信, 山越憲一: "電気的インピーダンス式心拍出量計測における最適電極配置と精度評価"第18回生体・生理工学シンポジウム論文集. 377-378 (2003)

Akira Igarashi、Kei Sasaki、Teruyoshi Moroe、Masamichi Nokawa、Shinobu Tanaka、Kenichi Yamakoshi：“电阻抗心输出量测量中的最佳电极放置和精度评估”第 18 届生物和生理工程研讨会论文集 377-378（2003 年）。

K.Yamakoshi, M.Nogawa, S.Tanaka et al.: "A New Proposal of Optimal Spot-electrode Array for Electrical Impedance Cardiography Through the Measurement of Thoracic Impedance Mapping"IEEE Engineering in Medicine and Biology Society 25th Annual International

K.Yamakoshi、M.Nokawa、S.Tanaka 等人：“A New Proposal of Optimal Spot- Electrode Array for Electrical Impedance Cardiography Through theMeasurement of Thoracic Impedance Mapping”IEEE Engineering in Medicine and Biology Society 25th Annual International

多用途小型循環動態モニターシステム

多功能紧凑型血流动力学监测系统

• 发表时间: 2003
• 期刊: 化学工業 54(8)
• 作者: 高樹枚;高塚浩子;野川雅道;田中志信;山越憲一;山越憲一
• 通讯作者: 山越憲一

G.Tanaka, S.Kawana, Y.Sawada, K.Yamakoshi: "Evaluation of pre-operative anxiety and propofol-induced sedation using newly proposed indices of finger vascular tone"Jap. Psychological Res.. 44(2). 91-98 (2002)

G.Tanaka、S.Kawana、Y.Sawada、K.Yamakoshi：“使用新提出的手指血管张力指数评估术前焦虑和异丙酚诱导的镇静”Jap。