Development of non-invasive and ambulatory monitoring system for cardiovascular haemodynamic parameters inclusive of cardiac output and blood pressure

开发心血管血流动力学参数（包括心输出量和血压）的非侵入式动态监测系统

• 批准号: 05555107
• 负责人: YAMAKOSHI Ken-ichi
• 金额: $ 6.14万
• 依托单位: Kanazawa University (1994-1995)Hokkaido University (1993)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05555107/
• 关键词: Non-invasive and ambulatory physiological measurement; Electrical admittance cardiography; Volume-oscillometric method; Cardiovascular haemodynamic variables; Human posture; Portable instrument; Cardiovascular function during daily activity; Home h

In recognition of the increasing need for health maintenance and disease prevention, an attempt was made to develop a non-invasive and ambulatory system capable of monitoring various cardiovascular parameters, naturally including cardiac output and blood pressure, during daily activities in a fully automatic manner. It is based on the electrical admittance cardiography and the volume-oscillometric method. The system mainly consists of (i) a finger cuff with a photo-plethysmographic sensor for detecting blood volume changes and tetra-polar electrodes for detecting the bio-admittance signal, (ii) a portable unit (104x64x32mm, 160g) which allows necessary measuring procedures and control, together with signal processing and data storage in a CMOS RAM,using a single-chip microcomputer, and (iii) data reproducing and analysing unit using a personal computer system. Asubject carries the former two during monitoring Long-term monitoring is made with a desired interval of 2,5 and 10 min preset … More , and after the monitoring the stored data are reproduced and analyzed by the computer, being displayd pulse rate (HR), pulse interval (PI), systolic (SBP)/meanMBP)/diastolic pressure (DBP), ventricular ejection time (Ts), stroke volume (SV), cardiac output (CO=HR・SV), peripheral vascular resistance (Rp=MBP/CO) and rate pressure product (RPP=HR・SBP) as an index of cardiac oxygen consumption in a trend manner.Besides the development of thissystem, a portable instrument for long-term ambulatory monitoring of human posture chnge has been designed, taking physiological importance and usefulness of such information along with cardiovascular haemodynamic parameters into consideration. It is based on the fact that almost all human postures in daily life, e. g. standing, sitting, lying, walking etc., can be estimated from the angles corresponding to the gravitational direction in three portions ; chest, thigh and lower leg. The instrument (58x94x25mm, 130g) includes preamplifiers, an A/D converter (6bit ; sampling interval, 0.1,0.2,0.5,1s), and a CMOS RAM (2MB) for storing the angles from electro-magnetic inclinometers placed on the three portions.Performance, availability and stability for monitoring by these two systems have been tested with successful and satisfactory results. Lots of 24-hour monitorings and data analyzes regarding the interactiive relation among the cardiovascular variables and the periodic construction of their circadian fluctuations using the maximum entropy method (MEM) have also been successfully made, suggesting that each proposed system appears promising as a method for use not only in further advanced basic and clinical cardiovascular researches but also in case of self care at home. Less

认识到对健康维护和疾病预防的需求日益增加，人们尝试开发一种能够在日常活动期间以全自动方式监测各种心血管参数（自然包括心输出量和血压）的非侵入性和流动系统。它是以心导纳图和容积法为基础的。该系统主要包括（i）具有用于检测血容量变化的光电体积描记传感器和用于检测生物导纳信号的四极电极的指套，（ii）便携式单元，（104 x64 x32 mm，160 g），它允许必要的测量程序和控制，以及信号处理和数据存储在CMOS RAM中，使用单片机，以及（iii）使用个人计算机系统的数据再现和分析单元。受试者在监测期间携带前两种药物。以预设的2、5和10分钟的预期间隔进行长期监测 ...更多信息 监测结束后，计算机再现并分析存储的数据，显示心率（HR）、脉搏间期（PI）、收缩压（SBP）/平均MBP）/舒张压（DBP）、心室射血时间（Ts）、每搏输出量（SV）、心输出量（CRD）、心搏输出量（CRD）、心率（HR）、脉搏间期（PI）、收缩压（SBP）/平均MBP/舒张压（DBP）、心室射血时间（Ts）、每搏输出量（SV）、心输出量（CRD）。（CO=HR·SV），外周血管阻力（Rp=MBP/CO）和速率压力乘积（RPP=HR·SBP）作为心脏耗氧量指标的趋势性研究。设计了一种便携式仪器，用于长期动态监测人体姿势变化，同时考虑到这些信息的生理重要性和有用性沿着心血管血液动力学参数。它是基于这样一个事实，即几乎所有的人类姿势在日常生活中，e。G.站着、坐着、躺着、走路等等，可以从对应于三个部分中的重力方向的角度来估计;胸部、大腿和小腿。该仪器（58 × 94 × 25 mm，130 g）包括前置放大器、A/D转换器（6 bit，采样间隔0.1，0.2，0.5，1 s）和CMOS RAM（2 MB），用于存储放置在三个部分上的电磁倾斜仪的角度。大量的24小时监测和数据分析之间的相互作用关系的心血管变量和周期性建设的昼夜节律波动，使用最大熵方法（MEM）也已成功，这表明每个建议的系统似乎有前途的方法，不仅用于进一步先进的基础和临床心血管研究，但在家庭自我保健的情况下。少

项目成果

沢田幸信 他: "実験室および日常生活における血行力学的昇圧機序の関連性" 医用電子と生体工学. 34(印刷中). (1996)

Yukinobu Sawada 等人：“实验室和日常生活中血流动力学升压机制的相关性”《医疗电子和生物工程》34（出版中）。

沢田 幸展: "ストレス刺激負荷時の血行動態に関する無侵襲計測と自律神経系調節機能の解析" 生体生理工学シンポジウム論文集. 8. 257-262 (1993)

Yukinobu Sawada：“应激刺激负荷期间血流动力学的非侵入性测量和自主神经系统调节功能的分析”生物生理工程研讨会论文集。8. 257-262 (1993)。

田中志信 他: "血圧・心拍出量を含む在宅循環動態モニタシステムによる日内変動解析の試み" 医用電子と生体工学. 34(印刷中). (1996)

Shishin Tanaka 等人：“尝试使用家庭血流动力学监测系统分析昼夜波动，包括​​血压和心输出量”《医疗电子和生物工程》34（出版中）。

田中志信,他: "無侵襲・無拘束循環生理機能計測と日内変動解析" 生体生理工学シンポジウム論文集. 9. 259-262 (1994)

Shinobu Tanaka 等人：“非侵入式无限制循环生理功能测量和昼夜变化分析”生物生理工程研讨会论文集。9. 259-262 (1994)

山越憲一(分担執筆): "アドバンスド・センサハンドブック" 培風館, 763 (1994)

Kenichi Yamakoshi（撰稿人）：《高级传感器手册》Baifukan，763 (1994)