Development of non-invasive and ambulatory monitoring system for cardiovascular haemodynamic parameters inclusive of cardiac output and blood pressure

开发心血管血流动力学参数（包括心输出量和血压）的非侵入式动态监测系统

• 批准号: 05555107
• 负责人: YAMAKOSHI Ken-ichi
• 金额: $ 6.14万
• 依托单位: Kanazawa University (1994-1995)Hokkaido University (1993)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05555107/
• 关键词: Non-invasive and ambulatory physiological measurement; Electrical admittance cardiography; Volume-oscillometric method; Cardiovascular haemodynamic variables; Human posture; Portable instrument; Cardiovascular function during daily activity; Home h

In recognition of the increasing need for health maintenance and disease prevention, an attempt was made to develop a non-invasive and ambulatory system capable of monitoring various cardiovascular parameters, naturally including cardiac output and blood pressure, during daily activities in a fully automatic manner. It is based on the electrical admittance cardiography and the volume-oscillometric method. The system mainly consists of (i) a finger cuff with a photo-plethysmographic sensor for detecting blood volume changes and tetra-polar electrodes for detecting the bio-admittance signal, (ii) a portable unit (104x64x32mm, 160g) which allows necessary measuring procedures and control, together with signal processing and data storage in a CMOS RAM,using a single-chip microcomputer, and (iii) data reproducing and analysing unit using a personal computer system. Asubject carries the former two during monitoring Long-term monitoring is made with a desired interval of 2,5 and 10 min preset … More , and after the monitoring the stored data are reproduced and analyzed by the computer, being displayd pulse rate (HR), pulse interval (PI), systolic (SBP)/meanMBP)/diastolic pressure (DBP), ventricular ejection time (Ts), stroke volume (SV), cardiac output (CO=HR・SV), peripheral vascular resistance (Rp=MBP/CO) and rate pressure product (RPP=HR・SBP) as an index of cardiac oxygen consumption in a trend manner.Besides the development of thissystem, a portable instrument for long-term ambulatory monitoring of human posture chnge has been designed, taking physiological importance and usefulness of such information along with cardiovascular haemodynamic parameters into consideration. It is based on the fact that almost all human postures in daily life, e. g. standing, sitting, lying, walking etc., can be estimated from the angles corresponding to the gravitational direction in three portions ; chest, thigh and lower leg. The instrument (58x94x25mm, 130g) includes preamplifiers, an A/D converter (6bit ; sampling interval, 0.1,0.2,0.5,1s), and a CMOS RAM (2MB) for storing the angles from electro-magnetic inclinometers placed on the three portions.Performance, availability and stability for monitoring by these two systems have been tested with successful and satisfactory results. Lots of 24-hour monitorings and data analyzes regarding the interactiive relation among the cardiovascular variables and the periodic construction of their circadian fluctuations using the maximum entropy method (MEM) have also been successfully made, suggesting that each proposed system appears promising as a method for use not only in further advanced basic and clinical cardiovascular researches but also in case of self care at home. Less

为了认识到对健康维持和疾病预防的需求日益增长，试图开发一种能够监测各种心血管参数的非侵入性和门诊系统，自然，包括心脏输出和血压，在日常活动中以全自动的方式进行。它基于电气验收心脏摄影和音量 - 尺度方法。 The system mainly consists of (i) a finger cuff with a photo-plethysmographic sensor for detecting blood volume changes and tetra-polar electrodes for detecting the bio-admittance signal, (ii) a portable unit (104x64x32mm, 160g) which allows necessary measuring procedures and control, together with signal processing and data storage in a CMOS RAM, using a single-chip microcomputer, and （iii）使用个人计算机系统的数据复制和分析单元。 Asubject carries the former two during monitoring Long-term monitoring is made with a desired interval of 2,5 and 10 min preset … More , and after the monitoring the stored data are reproduced and analyzed by the computer, being displayed pulse rate (HR), pulse interval (PI), systolic (SBP)/meanMBP)/diastolic pressure (DBP), ventricular ejection time (Ts), stroke volume (SV),心输出量（CO = HR・SV），周围血管抵抗（RP = MBP/CO）和费率压力产品（RPP = HR ・SBP）作为趋势的心脏氧气消耗指数。以趋势的方式开发了此类系统的发展，该系统的开发，可用于人类的长期仪器，并具有实用性的携带者，并具有实用性，并具有实用性，并具有良好的良好性，并有效地采用了无效的智能，并具有实用性血液动力学参数考虑到。这是基于以下事实：e。 g。站立，坐着，躺着，步行等，可以从对应于重力方向的角度，三部分，大腿和下腿的角度估算。该仪器（58x94x25mm，130g）包括前置放大剂，A/D转换器（6位；采样间隔，0.1,0.2,0.5,1s）和CMOS RAM（2MB），以将其在三个阶段的启用性和稳定性中验证，以使其在三个部分中存放在电磁倾斜度上的角度，并具有这些范围。还成功地进行了许多有关心血管变量之间的互动关系以及其昼夜节律波动的定期构建的24小时监控和数据分析，也已成功进行了成功，这表明每个提出的系统似乎都有希望，不仅可以在进一步的高级基本和临床心血管研究中使用，而且还可以在家中进行自我护理。较少的

项目成果

沢田 幸展: "ストレス刺激負荷時の血行動態に関する無侵襲計測と自律神経系調節機能の解析" 生体生理工学シンポジウム論文集. 8. 257-262 (1993)

Yukinobu Sawada：“应激刺激负荷期间血流动力学的非侵入性测量和自主神经系统调节功能的分析”生物生理工程研讨会论文集。8. 257-262 (1993)。

沢田幸信 他: "実験室および日常生活における血行力学的昇圧機序の関連性" 医用電子と生体工学. 34(印刷中). (1996)

Yukinobu Sawada 等人：“实验室和日常生活中血流动力学升压机制的相关性”《医疗电子和生物工程》34（出版中）。

田中志信 他: "血圧・心拍出量を含む在宅循環動態モニタシステムによる日内変動解析の試み" 医用電子と生体工学. 34(印刷中). (1996)

Shishin Tanaka 等人：“尝试使用家庭血流动力学监测系统分析昼夜波动，包括​​血压和心输出量”《医疗电子和生物工程》34（出版中）。

山越憲一(分担執筆): "アドバンスド・センサハンドブック" 培風館, 763 (1994)

Kenichi Yamakoshi（撰稿人）：《高级传感器手册》Baifukan，763 (1994)

田中志信,他: "無侵襲・無拘束循環生理機能計測と日内変動解析" 生体生理工学シンポジウム論文集. 9. 259-262 (1994)

Shinobu Tanaka 等人：“非侵入式无限制循环生理功能测量和昼夜变化分析”生物生理工程研讨会论文集。9. 259-262 (1994)