A study on Non-invasive Multifunctional Measurements of Circulatry Parameters Using Bio-electrical and Photo-plethysmography Techniques

利用生物电和光电体积描记技术无创多功能测量循环参数的研究

• 批准号: 02454031
• 负责人: YAMAKOSHI Ken-ichi
• 金额: $ 4.22万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-02454031/
• 关键词: bioelectrical and photoelectrical tissue characteristics; non-invasive physiological measurement; multifunctional measurement; cardiovascular haemodynamics; volume-oscillometric method; volume-compensation method; photoelectric plethysmography; ele

The present era, with accelerated aging of the population, has an increased need for early diagnosis and treatment of cardiovascular diseases such as heart disease, arteriosclerosis and cerebral apoplexy. For this purpose, there has been a requirement for simple and convenient instrumentation capable of quantitative evaluation of circulatory parameters. Non-invasive measurements which inflict little pain and/or injury are preferable in clinical use. Simultaneous measurement of physiological parameters with the least number of sensing techniques will also be more desirable for screening tests and home care use as well, which will provide an achievement of great social contribution. This research project conducted with such aims to provide a new simple technique for non-invasive and simultaneous physiological measurements based on our innovative sphygmomanometry called "volume-oscillometric(O) and volume-compensation (VC) method" and electrical admittance plethysmography(ADM) proposed pr … More eviously, and following significant results were successfully obtained. (1) A new simultaneous measurement of blood pressure,cardiac output,peripheral vascular resistance,and other important cardiovascular parameters has been proposed in combination of the VO or VC method and the ADM technique. A tetra-polar volume-clamp method has been newly designed for accurate and reliable detection of bio-electrical admittance signal. (2) Arlcrial elastic property in the human limbs has been successfully assessed as a function of blood pressure by measuring quantitavely blood volume changes with an infra-red photo-plethysmography and the ADM technique based on the VO method. (3) A new technique has been designed for the measurement of blood pressure as well as oxygenation of arterial and venous blood using a spectro-photometry based on the VO method. (4) An electrical admittance-cuff method has been newly proposed for the multifunctional and simultaneous measurement of blood pressure, blood flow, arterial and venous elasticity, haematocrit, capillary pressure, capillary filtration coefficient and so on in human limbs. With this method, several physiological findings were non-invasively revealed during exercise testing in terms of regulation of peripheral circulation. (5) Further developments such as long-term ambulatory cardiovascular measurements have been successfully progressed for clinical and home care use, obtaining considerably significant and interesting physiological findings which could not be got by conventional methods. Through these investigations, the present project would serve quite significant contributions in many fields of biomedical engineering, providing a practical multifunctional system for the non-invasive measurement and analysis of cardiovascular haemodynamics. Less

随着人口老龄化的加速，当今时代对诸如心脏病、动脉硬化和脑中风的心血管疾病的早期诊断和治疗的需求增加。为此，需要能够定量评价循环参数的简单方便的仪器。在临床使用中，最好是造成很少疼痛和/或损伤的非侵入性测量。用最少数量的感测技术同时测量生理参数对于筛查测试和家庭护理使用也将是更期望的，这将提供巨大社会贡献的成就。本研究的目的是基于我们的创新性血压测量方法--容积-容积-补偿（VC）法和电导纳体积描记法（ADM），提供一种新的简单的无创性同步生理测量方法。 ...更多信息 并且成功地获得了以下显著的结果。(1)结合VO或VC方法和ADM技术，提出了一种新的同时测量血压、心输出量、外周血管阻力和其他重要心血管参数的方法。为了准确可靠地检测生物电导纳信号，设计了一种新的四极容积钳方法。(2)本文用红外线光体积描记法和基于VO法的ADM技术定量测量了人体肢体的血容量变化，成功地评价了人体肢体的动脉弹性随血压的变化。(3)本文提出了一种基于VO法的分光光度法测量动脉血和静脉血的血压和氧合的新技术。(4)本文提出了一种新的电导纳袖带法，可同时测量人体四肢的血压、血流量、动、静脉弹性、红细胞压积、毛细血管压力、毛细血管滤过系数等。通过这种方法，在运动测试期间非侵入性地揭示了外周循环调节方面的几个生理学发现。(5)进一步的发展，如长期动态心血管测量已成功地进展为临床和家庭护理使用，获得相当显着和有趣的生理结果，这是不能通过传统的方法。通过这些研究，本项目将在生物医学工程的许多领域做出重大贡献，为心血管血流动力学的无创测量和分析提供实用的多功能系统。少

项目成果

山越 憲一: "非侵襲血圧モニタ-" 臨床モニタ-. 2. 31-40 (1991)

Kenichi Yamakoshi：“无创血压监测仪”《临床监测》2. 31-40 (1991)。

伊藤 寛志他: "インピ-ダンス・カフ法を用いた体肢血流、血液比抵抗、ヘマトクリットの無侵襲同時計測法" 医用電子と生体工学. 28. 444 (1990)

Hiroshi Ito 等人：“使用阻抗袖带法非侵入性同时测量肢体血流、血液电阻率和血细胞比容”《医疗电子与生物工程》28. 444 (1990)。

Yamakoshi K: "Non-invasive and ambulatory physiological measurements" Byoutai-Seiri. Vol.10,No.6. 477-487 (1991)

Yamakoshi K：“非侵入性动态生理测量”Byoutai-Seiri。

Ando J, Kawarada A, Shibata M, Yamakoshi K & Kamiya A: "Pressure-volume relationships of finger arteries in healthy subjects and patients with coronary atherosclerosis measured non-invasively by photoelectric plethysmography" Jap Circ J. Vol.55,No.6. 567-

安藤 J、河原田 A、柴田 M、山越 K

Yamakoshi K: "Non-invasive techniques for ambulatory blood pressure monitoring and simultaneous cardiovascular measurements" J Ambul Monit. Vol.4,No.2. 123-143 (1991)

Yamakoshi K：“动态血压监测和同步心血管测量的非侵入性技术”J Ambul Monit。