Study on the autonomic regulation analysis of cardiovascular system using non-invasive and ambulatory system for monitoring instantaneous blood pressure and cardiac interbeat interval

利用无创动态血压和心跳间隔监测系统对心血管系统自主调节分析的研究

• 批准号: 06454722
• 负责人: YAMAKOSHI Ken-ichi
• 金额: $ 4.48万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454722/
• 关键词: Non-invasive and ambulatry cardiovascular monitoring; Cardiovascular regulatory function; Autonomic regulation; Sympathetic; vagal nerve activity; Baroreceptor-cardiac reflex; Volume-compensation method; Instantaneous blood pressure; Spectral anal

In order to analyze autonomic regulation of cardiovascular system during daily life activities, a non-invasive and ambulatory system (160x140x45mm, 700gf) has been newly designed, which can automatically monitor systolic (SBP) /mean (MBP) /diastolic pressure (DBP), pulse interval (P-P), inter-beat interval (IBI) and respiration interval (ReP) from ECG waveform on a beat-by-beat basis. Principle of blood pressure measurement is based on the volume-compensation method using vascular unloading, previously proposed by us. 6 time-series data are recorded in an IC memory card after necessary signal processings using a single-chip microcomputer with an interactive software, altogether about 700,000 beats of data being stored. After the monitoring, these stored data are reproduced, displayd on a CRT monitor, and performed necessary analyzes using a conventional personal computer. Taking physiological importance of the effect of human posture changes on the cardiovascular variables into conside … More ration, a portable instrument for long-term ambulatory monitoring of the posture chnges has been also designed in parallel with the development of the present system. This measurement is based on the fact that almost all human postures in daily life can be estimated from the angles corresponding to the gravitational direction in three portions ; chest, thigh and lower leg. The instrument (58x94x25mm, 130g) can store these angles in a CMOS RAM (2MB) using electro-magnetic inclinometers placed on the three portions, and easily be used together with the above system if rewuired under an experimental situation.In this study, autonomic regulatory function of the cardiovascular system was assessed by (i) baroreceptor-cardiac reflex sensitivity (BRS) obtained by computerised scanning of beat-by-beat SBP and PP (or IBI) values, (ii) transfer function calculated by power and cross spectra of SBP and IBI data, and (iii) spectral analysis of SBP and IBI data using a naximum entropy method, which were performed by a personal computer-based system.Using young (20-24 years old, male) healthy subjects, data were collected under daily life activities and categorized into 9 physical activities ; supine (rest), siting (rest), desk work on a chair, standing, working during standing without movement, walking, up and down the stairs, and bicycle exercise. It is demonstrated that the BRS values and power spectral density of IBI data over high frequency (HF) range of 0.15-0.5 Hz were significantly reduced following the increase in the physical activities, indicating that vagal nerve activity would be depressed by the increase in the physical activities. This phenomenon was also confirmed by the gain of the transfer function at higher values of the coherence over low frequency (LF) range of 0.04-0.12 Hz and HF range. However, power spectral densities of IBI and SBP data over LF range showed no significant correlation with the physical activities, indicating that LF powers of both SBP and IBI might be modulated by the vagal and sympathetic nerve activity against the physical activities and thus not be a significant index to assess only the sympathetic activity. Through these findings, we conclude that further development of ambulatory system capable of monitoring both blood pressure and cardiac output (and thus peripheral vascular resistance) should be desired to evaluate in detail the sympathetic activity during daily life. Less

为了分析日常生活活动中心血管系统的自主调节功能，设计了一种无创便携式心电监护系统（160 × 140 × 45 mm，700 gf），该系统可根据心电波形逐拍自动监测收缩压（SBP）/平均压（MBP）/舒张压（DBP）、脉搏间期（P-P）、心搏间期（IBI）和呼吸间期（ReP）。血压测量的原理是基于我们以前提出的使用血管卸载的体积补偿方法。6个时间序列数据在使用具有交互式软件的单片微型计算机进行必要的信号处理之后被记录在IC存储卡中，总共存储约700，000拍的数据。在监视之后，这些存储的数据被再现，显示在CRT监视器上，并使用常规的个人计算机进行必要的分析。考虑到人体姿势变化对心血管变量影响的生理重要性， ...更多信息 在本系统的开发过程中，还设计了一种用于长期动态监测姿势变化的便携式仪器Ration。这种测量是基于这样一个事实，即几乎所有的人在日常生活中的姿势可以估计从相应的三个部分的重力方向的角度;胸部，大腿和小腿。仪器（58 × 94 × 25 mm，130 g）的三个部分上分别安装了电磁倾角仪，可将测得的角度值存储在一个2 MB的CMOS RAM中，在实验条件下，可方便地与上述系统配合使用。心血管系统的自主调节功能通过（i）压力感受器-心脏反射敏感性（BRS）来评估，（ii）通过SBP和IBI数据的功率和交叉谱计算的传递函数，以及（iii）使用最大熵方法的SBP和IBI数据的谱分析，这些都是通过基于个人计算机的系统进行的。（20-24岁，男性）健康受试者，在日常生活活动下收集数据，并将其分类为9种身体活动;仰卧（休息），坐着（休息），在椅子上做案头工作，站立，站立时工作，步行，上下楼梯和自行车运动。结果表明，随着体力活动的增加，0.15- 0.5Hz高频IBI数据的BRS值和功率谱密度显著降低，表明迷走神经活动会受到体力活动的抑制。该现象也通过在0.04-0.12 Hz的低频（LF）范围和HF范围上的较高相干值处的传递函数的增益来证实。然而，LF范围内IBI和SBP数据的功率谱密度与体力活动无显著相关性，表明SBP和IBI的LF功率可能受到迷走神经和交感神经活动的调制，因此不能仅作为评估交感神经活动的重要指标。通过这些研究结果，我们得出结论，进一步发展能够监测血压和心输出量（从而外周血管阻力）的动态系统，应详细评估在日常生活中的交感神经活动。少

项目成果

乙丸砂絵 他: "無拘束連続血圧・心電モニタによる日常行動に対する自律神経系循環調節反応の解析" 医用電子と生体工学. 35(in press). (1997)

Sunae Otomaru 等人：“使用不受限制的连续血压和心电图监测分析自主神经系统循环调节反应”，《医疗电子和生物工程》35（出版中）。

田中志信 他: "姿勢及び連続血圧の無拘束同時計測による日常生活下の血圧調節機構解析の試み" 医用電子と生体工学. 33. 151- (1995)

Shinobu Tanaka 等：“通过无限制地同时测量姿势和连续血压来分析日常生活中的血压调节机制”《医疗电子与生物工程》33. 151- (1995)。

Sawada,Y.et al: "A new technique of time series analysis by combining maximum entropy method and nonlinear least squares method and its application for an assessment of cardiac autonomic activity" Med.& Biol.Eng.& Comput.(in press). (1996)

Sawada，Y.et al：“结合最大熵法和非线性最小二乘法的时间序列分析新技术及其在心脏自主活动评估中的应用”Med。

沢田幸展 他: "無侵襲循環動態計測による自律神経系調節機能の解析" 生体生理工学シンポジウム論文集. 9. 235-238 (1994)

Yukinobu Sawada 等人：“通过无创血流动力学测量分析自主神经系统调节功能”生物生理工程研讨会论文集 9. 235-238 (1994)。

Otomaru, S.et al.: "Assessment of autonomic regulatory function in ambulant subjects using a newly designed portable system for monitoring beat-to-beat blood pressure together with human posture" Tech.Rept.MBE96-7. 41-46 (1996)

Otomaru, S.et al.：“使用新设计的便携式系统评估移动受试者的自主调节功能，用于监测逐次血压和人体姿势”Tech.Rept.MBE96-7。