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Molecular characterization of volume-activated anion channels and elucidation of cell death-survival switching mechanisms

Molecular characterization of volume-activated anion channels and elucidation of cell death-survival switching mechanisms
体积激活阴离子通道的分子表征和细胞死亡-生存转换机制的阐明
批准号：
21249010
负责人：
OKADA Yasunobu
金额：
$30.2万
依托单位：
National Institute for Physiological Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2009
资助国家：
日本
项目状态：
已结题
起止时间：
2009-04-01 至 2013-03-31
来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249010/
关键词：
容積感受性アニオンチャネルマキシアニオンチャネル酸感受性アニオンチャネル細胞容積調節アポトーシスネクローシス虚血性細胞死ATP放出細胞死TRPM7ABCF2

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中文摘要
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英文摘要
In the present study, several types of anion channels, which are involved in cell death-survival switching, were investigated, and the followings were elucidated: 1. Reactive oxygen species (ROS) or dissociation of ABCF2 and protein tyrosine dephosporylation are involved in activation of VSOR and Maxi-Cl, respectively. 2. Three and two candidates were selected as the candidate molecules for VSOR and Maxi-Cl, respectively. 3. Rescue from apoptotic, necrotic and ischemic cell death is induced by regulating the activities of VSOR, ASOR and CFTR anion channels.
期刊论文(53)
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会议论文
Protective Role of Cardiac CFTR Activation Upon Early Reperfusion Against Myocardial Infarction
DOI： 10.1159/000341479
发表时间： 2012-09
期刊： Cellular Physiology and Biochemistry
影响因子： --
作者： [H. Uramoto;Toshiaki Okada;Yasunobu Okada]
通讯作者： H. Uramoto;Toshiaki Okada;Yasunobu Okada
Volume-sensitive outwardly rectifying chloride channel in white adipocytes from normal and diabetic mice.
正常和糖尿病小鼠白色脂肪细胞中体积敏感的外向整流氯离子通道。
DOI： --
发表时间： 2010
期刊： Am.J.Physiol.Cell Physiol.
影响因子： --
作者： [H.Inoue, N.Takahashi, Y.Okada, M.Konishi]
通讯作者： M.Konishi
Maxi-anion channel and pannexin 1 hemichannel constitute separate pathways for swelling-induced ATP release in murine L929 fibrosarcoma cells.
DOI： 10.1152/ajpcell.00459.2011
发表时间： 2012-11
期刊： American journal of physiology. Cell physiology
影响因子： --
作者： [Md. Rafiqul Islam;H. Uramoto;Toshiaki Okada;R. Sabirov;Y. Okada]
通讯作者： Md. Rafiqul Islam;H. Uramoto;Toshiaki Okada;R. Sabirov;Y. Okada
細胞死のチャネルメカニズムとその病態
细胞死亡通道机制及其病理
DOI： --
发表时间： 2013
期刊： 日本病態生理学会雑誌
影响因子： --
作者： [KITA, Yasuyuki, et al., 岡田泰伸]
通讯作者： 岡田泰伸
共 38 条
    Mechanisms of interaction between the volume-sensitive outwardly rectifying anion channel, VSOR, and a novel membrane protein, LRRC8A.
    • 批准号：
      15K15028
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2015
    • 负责人：
      OKADA Yasunobu
    • 依托单位：
      The Graduate University for Advanced Studies
    Studies on temperature sensitivity and molecular identity of the acid-sensitive outwardly rectifying anion channel (ASOR) in neurons in relation to the mechanism of hypothermic neuroprotection
    Elucidation of hypotonicity-induced suppression mechanism of vasopressin secretion through identification of hypoosmolarity sensor
    • 批准号：
      23659118
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2011
    • 负责人：
      OKADA Yasunobu
    • 依托单位：
      National Institute for Physiological Sciences
    Channel-mediated mechanisms of induction of and protection against cell death
    海外基金