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Elucidation of hypotonicity-induced suppression mechanism of vasopressin secretion through identification of hypoosmolarity sensor

Elucidation of hypotonicity-induced suppression mechanism of vasopressin secretion through identification of hypoosmolarity sensor
通过鉴定低渗透压传感器阐明低渗引起的加压素分泌抑制机制
批准号：
23659118
负责人：
OKADA Yasunobu
金额：
$2.41万
依托单位：
National Institute for Physiological Sciences
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2012
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659118/
关键词：
浸透圧センサーバソプレシン視索上核アニオンチャネルタウリングリシンレセプター低浸透圧センサーバソプレシン視索上核

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中文摘要
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英文摘要
Arginine-vasopressin (AVP), an antidiuretic hormone, is secreted from AVP neurons in a manner sensitive to body fluid osmolarity. The current view for the hypotonicity-induced suppression mechanism consists of following two hypotheses: Reduced depolarization due to inactivation of stretch-inactivated cation channel (SIC) in osmotically swollen AVP neurons, and increased hyperpolarization due to glycine receptor (GlyR) activation in AVP neurons in response to taurine released from osmotically swollen glial cells. In rat AVP neurons, in the present study, the SIC activity was not observed, and taurine-induced activation of GlyR brought about depolarization but not hyperpolarization under hypotonic conditions. Also, the present study showed that taurine-releasing anion channel activated by cell swelling serves as a sensor for hypoosmolarity.
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Volume-regulatory autocrine action of vasopressin released from somata and dendrites in vasopressin neurons is mediated by the V2 receptor and cAMP
加压素神经元体细胞和树突释放的加压素的容量调节自分泌作用由 V2 受体和 cAMP 介导
DOI： --
发表时间： 2011
期刊：
影响因子： --
作者： [Kaori Sato, Tomohiro Numata, Takeshi Saito, Yoichi Ueta, Yasunobu Okada]
通讯作者： Yasunobu Okada
Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells
DOI： 10.1002/jcp.24050
发表时间： 2012-10-01
期刊： JOURNAL OF CELLULAR PHYSIOLOGY
影响因子： 5.6
作者： [Ando-Akatsuka, Yuhko, Shimizu, Takahiro, Okada, Yasunobu]
通讯作者： Okada, Yasunobu
生理学研究所HP&機能協関研究部門 HP:公開日 2013.01.31 抗酸化物質グルタチオンが細胞から放出 される「通り道」を発見:Sabirov RZ, Kurbannazarova RS, Melanova NR, Okada Y. Volume-sensitive anion channels mediate osmosensitive glutathione release from rat thymocytes. PLoS One, 2013
国立生理科学研究所 HP 和功能协作研究部 HP：出版日期 2013.01.31 发现细胞释放抗氧化剂谷胱甘肽的“途径”：Sabirov RZ、Kurbannazarova RS、Melanova NR、Okada Y. 体积敏感阴离子通道介导大鼠胸腺细胞的渗透敏感性谷胱甘肽释放 PLoS One，2013 年。
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Study on the hypoosmolarity sensing mechanism in arginine-vasopressin neurons: Reexamination on the taurine hypothesis
精氨酸-加压素神经元低渗感知机制的研究：牛磺酸假说的重新审视
DOI： --
发表时间： 2013
期刊：
影响因子： --
作者： [Kaori Sato-Numata, Yoichi Ueta and Yasunobu Okada]
通讯作者： Yoichi Ueta and Yasunobu Okada
共 13 条
    Mechanisms of interaction between the volume-sensitive outwardly rectifying anion channel, VSOR, and a novel membrane protein, LRRC8A.
    • 批准号：
      15K15028
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.41万
    • 财政年份：
      2015
    • 负责人：
      OKADA Yasunobu
    • 依托单位：
      The Graduate University for Advanced Studies
    Studies on temperature sensitivity and molecular identity of the acid-sensitive outwardly rectifying anion channel (ASOR) in neurons in relation to the mechanism of hypothermic neuroprotection
    Molecular characterization of volume-activated anion channels and elucidation of cell death-survival switching mechanisms
    Channel-mediated mechanisms of induction of and protection against cell death