Endocrine interaction of brain and gut that governs seawater adaptation in fishes
大脑和肠道的内分泌相互作用控制鱼类的海水适应
基本信息
- 批准号:23247010
- 负责人:
- 金额:$ 31.2万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Marine teleosts drink copiously and absorb 90% of ingested seawater by the intestine to cope with osmotic dehydration. Thus, drinking and subsequent absorption of water by the intestine is essential to survive in hyperosmotic marine environment. The transcriptome analyses showed that the brain (regulatory site for drinking) and the gut (regulatory site for absorption) express several hormone genes and their expression is upregulated after transfer of eels to seawater. Furthermore, the brain and the gut interact with each other by regulating drinking and intestinal absorption through blood stream or via innervated nerves. We are currently performing tissue-specific knockdown of such important genes in medaka to evaluate their roles in seawater adaptation. This is the first study that demonstrate interactions between brain and gut via hormones for seawater adaptation.
海洋硬骨鱼大量饮水,肠道吸收90%的海水以科普渗透性脱水。因此,饮水和随后的肠道吸收水是在高渗海洋环境中生存所必需的。转录组分析表明,脑(饮用的调节位点)和肠道(吸收的调节位点)表达几种激素基因,它们的表达上调后,鳗鱼转移到海水。此外,大脑和肠道通过血流或神经支配的神经调节饮水和肠道吸收而相互作用。我们目前正在进行组织特异性敲除这些重要的基因在青鳉,以评估其在海水适应的作用。这是第一项证明大脑和肠道之间通过激素相互作用以适应海水的研究。
项目成果
期刊论文数量(151)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hormonal control of drinking behavior in fish
鱼类饮水行为的激素控制
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Takei;Y.;Nobata;S.;and Ando;M.
- 通讯作者:M.
海水ウナギの延髄最後野ニューロンの飲水調節ホルモンに対する応答
延髓后咸水鳗神经元对饮水调节激素的反应
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Yutetsu Kuruma;Hideaki Matsubayashi;Takuya Ueda;安藤正昭
- 通讯作者:安藤正昭
Functional analyses of the cardiac natriuretic peptides in medaka using a knockdown technology
使用敲低技术对青鳉中的心脏利钠肽进行功能分析
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:Miyanishi;H.
- 通讯作者:H.
Eel Physiology (F. Trischitta, Y. Takei, and P. Sebert eds.)
鳗鱼生理学(F. Trischitta、Y. Takei 和 P. Sebert 编辑)
- DOI:
- 发表时间:2014
- 期刊:
- 影响因子:0
- 作者:Ando;M. and Takei;Y.
- 通讯作者:Y.
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TAKEI Yoshio其他文献
TAKEI Yoshio的其他文献
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{{ truncateString('TAKEI Yoshio', 18)}}的其他基金
Evolution of drinking mechanism from aquatic to terrestrial habitat : Exploring its origin using fishes
从水生到陆地栖息地的饮水机制的演变:利用鱼类探索其起源
- 批准号:
19207005 - 财政年份:2007
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Search for the genes responsible for adaptation to marine environments: osmoregulatory hormone genes
寻找负责适应海洋环境的基因:渗透调节激素基因
- 批准号:
16207004 - 财政年份:2004
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Natriuretic peptides govern euryhalinity of fishes Analyses using transgenid technology
利钠肽控制鱼类的广盐度 使用转基因技术进行分析
- 批准号:
13304063 - 财政年份:2001
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
C-type natriuretic peptie as a paracrine and an endocrine hormone
C 型钠尿肽作为旁分泌激素和内分泌激素
- 批准号:
06454020 - 财政年份:1994
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Hormonal Control of osmoregulation in euryhaline fis
广盐鱼渗透压调节的激素控制
- 批准号:
06044270 - 财政年份:1994
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for Overseas Scientific Survey.
Physiological actions of a family of natriuretic peptides in eels
鳗鱼钠尿肽家族的生理作用
- 批准号:
04640691 - 财政年份:1992
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Application of Recapitulation Theory to Secretion of Atrial Natriuretic Peptide
重演理论在心房钠尿肽分泌中的应用
- 批准号:
02640584 - 财政年份:1990
- 资助金额:
$ 31.2万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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