A functional imaging study of semantic processing modulated by dopamine

多巴胺调节语义加工的功能成像研究

• 批准号: DP0452264
• 负责人: Prof David Copland
• 金额: $ 19.44万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0452264
• 关键词: functional; imaging; study; semantic; processing

The role of dopamine in language processing is largely unknown, despite emerging evidence that dopaminergic alterations can modulate language in schizophrenia, Parkinson's disease, and healthy individuals. The research aims to reveal the neural and behavioural correlates of dopaminergic modulation of semantic processing using neuroimaging in healthy individuals who have ingested levodopa. It is hypothesised that levodopa will modulate brain activity under circumstances where there is heightened semantic competition, consistent with a contemporary theory of dopaminergic cognitive control. The expected outcome of the research is an increased understanding of the interactions between dopamine, the language faculty, and associated neural systems.

尽管有新的证据表明多巴胺能改变可以调节精神分裂症、帕金森病和健康个体的语言，但多巴胺在语言处理中的作用在很大程度上尚不清楚。该研究旨在利用神经影像学对摄入左旋多巴的健康个体揭示多巴胺能调节语义处理的神经和行为相关性。据推测，左旋多巴将在语义竞争加剧的情况下调节大脑活动，这与当代多巴胺能认知控制理论一致。该研究的预期结果是加深对多巴胺、语言能力和相关神经系统之间相互作用的理解。