Optical imaging of brain activity: Studies of the neural basis of sensory perception, plasticity and behaviour

大脑活动的光学成像：感官知觉、可塑性和行为的神经基础研究

• 批准号: LE0452971
• 负责人: Prof Trichur Vidyasagar
• 金额: $ 6.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-12-11 至 2006-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE0452971
• 关键词: Optical; imaging; brain; activity; Studies

Basic to the understanding of the brain is to know how the overall architecture of the nervous system relates to its function. We propose to study this by directly visualising the regions that are functionally active in the living brains of animals, down to resolution limits of less than 100 micrometres. Such "optical imaging" will be done by recording light reflected from the surface of the brain, which in turn depends upon activity-dependent intrinsic signals (eg. degree of oxygenation of haemoglobin). These signals will be recorded by a special camera and amplified using the requested system.

了解大脑的基础是了解神经系统的整体结构与其功能的关系。 我们建议通过直接可视化动物活体大脑中功能活跃的区域来研究这一点，分辨率限制低于100微米。 这种“光学成像”将通过记录从大脑表面反射的光来完成，这反过来取决于活动依赖的内在信号（例如，大脑的反射）。血红蛋白的氧合程度）。这些信号将由一个特殊的摄像机记录，并使用所要求的系统放大。