600 MHz-spectrometer with probes and autosampler

带探头和自动进样器的 600 MHz 光谱仪

• 批准号: 519222575
• 金额: --
• 依托单位: Universität Leipzig
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/519222575?language=en
• 关键词: 600; MHz; spectrometer; probes; autosampler

A 600 MHz NMR instrument with a highly sensitive nitrogen-cooled probe is requested to enhance the performance and the methodological spectrum of the NMR Core Facility at the Institute of Organic Chemistry of Leipzig University. The acquisition of the new NMR instrument will meet the current requirements for NMR service, which have been significantly increased due to the new appointments of the Faculty of Chemistry and Mineralogy at Leipzig University, Prof. Tanja Gulder (Institute for Organic Chemistry) and Prof. Jens Meiler (Institute for Drug Development). These appointments have been accompanied by establishing new research activities at and in between the participating institutes and, consequently, by a general increase in the demand for NMR service and measurements. In addition, new NMR services for high-throughput NMR experiments in the context of e.g. the development of enzymes as biocatalysts by directed evolution, as well as of pharmaceutically active agents are needed. In both research areas, investigations on structure-activity relationships by small molecule-protein interactions are necessary, requiring the procurement of an autosampler with 500 positions. With this, the maximum capacity of the installation of a highly sensitive probe in terms of efficiency will be achieved.

需要一台带有高灵敏度氮冷却探头的600 MHz NMR仪器，以提高莱比锡大学有机化学研究所NMR核心设施的性能和方法谱。购买新的NMR仪器将满足当前对NMR服务的需求，由于莱比锡大学化学和矿物学学院Tanja Gulder教授（有机化学研究所）和Jens Meiler教授（药物开发研究所）的新任命，NMR服务的需求显着增加。这些任命伴随着在参与研究所内和参与研究所之间建立新的研究活动，因此，对核磁共振服务和测量的需求普遍增加。此外，在例如通过定向进化开发作为生物催化剂的酶以及药物活性剂的背景下，需要用于高通量NMR实验的新NMR服务。在这两个研究领域中，通过小分子-蛋白质相互作用对结构-活性关系进行调查是必要的，需要采购具有500个位置的自动进样器。这样，就可以实现高灵敏度探头在效率方面的最大安装能力。