600 MHz-spectrometer with probes and autosampler

为了提高莱比锡大学有机化学研究所核磁共振核心装置的性能和方法学谱，需要一台600 MHz高灵敏度氮冷探针核磁共振仪器。收购新的核磁共振仪器将满足目前对核磁共振服务的要求，由于莱比锡大学化学和矿物学学院Tanja Gulder教授（有机化学研究所）和Jens Meiler教授（药物开发研究所）的新任命，核磁共振服务的要求大大增加。这些任命伴随着在参与机构之间建立新的研究活动，因此，对核磁共振服务和测量的需求普遍增加。此外，需要新的核磁共振服务，用于高通量核磁共振实验，例如，通过定向进化开发作为生物催化剂的酶，以及药物活性剂。在这两个研究领域中，通过小分子-蛋白质相互作用来研究结构-活性关系是必要的，需要采购具有500个位置的自动进样器。这样，在效率方面将实现高灵敏度探头安装的最大容量。

A 600 MHz NMR instrument with a highly sensitive nitrogen-cooled probe is requested to enhance the performance and the methodological spectrum of the NMR Core Facility at the Institute of Organic Chemistry of Leipzig University. The acquisition of the new NMR instrument will meet the current requirements for NMR service, which have been significantly increased due to the new appointments of the Faculty of Chemistry and Mineralogy at Leipzig University, Prof. Tanja Gulder (Institute for Organic Chemistry) and Prof. Jens Meiler (Institute for Drug Development). These appointments have been accompanied by establishing new research activities at and in between the participating institutes and, consequently, by a general increase in the demand for NMR service and measurements. In addition, new NMR services for high-throughput NMR experiments in the context of e.g. the development of enzymes as biocatalysts by directed evolution, as well as of pharmaceutically active agents are needed. In both research areas, investigations on structure-activity relationships by small molecule-protein interactions are necessary, requiring the procurement of an autosampler with 500 positions. With this, the maximum capacity of the installation of a highly sensitive probe in terms of efficiency will be achieved.