权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Genetic Analysis of the Dento-Facial Growth and Development.

牙面部生长和发育的遗传分析。

基本信息

批准号：
60440092
负责人：
NAKATA Minoru
金额：
$ 16.45万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1985
资助国家：
日本
起止时间：
1985 至 1988
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60440092/
关键词：
Oral-Facial Genetics Growth Genetics 母体効果歯・顎・顔面受精卵移植歯顎顔面

项目摘要

The continuous variables, such as tooth size and jaw size, are characters that can be measured against a continuous scale. Such continuous variables usually have a multifactorial basis ; that is, several genes and environmental influences, each with a relatively small effect, contribute to an individual position on the continuous scale.Multivactorial inheritance, also known as polygenis or quantitative inheritance, is not easy to analyze, but a number of method have been developed to demonstrate it. The simplest of these is the method of resemblance between relatives ; that is, the demonstration that the more closely related two individuals are, the more closely they resemble each other in the trait in question.Based on the genetic study using the experimental animals it was indicated that there is the antagonistic "behavior" between the genetic and maternal factor through all experimental periods for each segment of the craniofacial complex. The maternal effect disappears earlier in females than males, and appears related to the fact that females attain adult size earlier than males. In the early stages of dento-facial growth, the main source of the variation is attributed to variance on the maternal effect, and later as the maternal effect decreases or disappears, the genetic effect becomes a more significant factor in determining the dento-facial size.

连续变量，例如牙齿尺寸和下巴尺寸，是可以根据连续尺度进行测量的特征。此类连续变量通常具有多因素基础；也就是说，几个基因和环境影响，每一个都具有相对较小的影响，在连续尺度上对个体位置做出贡献。多向量遗传，也称为多基因遗传或定量遗传，并不容易分析，但已经开发了许多方法来证明它。其中最简单的是亲戚之间的相似法；也就是说，两个个体的关系越密切，他们在相关特征上就越相似。基于使用实验动物进行的遗传学研究表明，在所有实验期间，颅面复合体的每个部分的遗传因素和母体因素之间都存在着对抗性的“行为”。母性效应在雌性中比雄性更早消失，这似乎与雌性比雄性更早达到成年体型这一事实有关。在牙面部生长的早期阶段，变异的主要来源是母体效应的差异，后来随着母体效应的减弱或消失，遗传效应成为决定牙面部大小的更重要因素。