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Pathophysiological studies of hypofibronectineamia and superoxide radical in multiple organ failure (MOF)

多器官衰竭（MOF）中低纤维连接血症和超氧自由基的病理生理学研究

基本信息

批准号：
61570599
负责人：
KASAI Shinichi
金额：
$ 1.41万
依托单位：
Asahikawa Medical College
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1986
资助国家：
日本
起止时间：
1986 至 1987
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61570599/
关键词：
MOF fibronectine superoxide radical liver failure severe sepsis reticuloendothelial system 網内系機能

项目摘要

Multiple organ failure (MOF) is a syndrome which may occur in patients after injuey or after operation. This syndrome is the natural result of improved surgical capability and care of patients, but is still sometimes fatal. Recently, it has been pointed out that the main pathophysiology of the syndrome is severe sepsis observed in injured or surgical patients. These patients are usually impaired reticuloendothelial host defense mechanisms and serum fibronectin of these patients is often low.While it has been noticed that the formation of oxygen-derived free radical may play an important part in somekinds of tissue injuries. Thus is this study, we design to investigate the patophysiological interrelationship between hypofibronectinemia and super oxide radical in MOF.1. Plasma fibronectine in clinical patients;The were observed that the level of plasma fibronectine decreased remarkably in patients with severe sepsis and liver failure. The level also decreased just after surgical insertion, but it again increased in usual course by one week.2. Experimental studies;i) Plasma fibronectine level decreased in rats with abdominal infection and the animals died by severe sepsis.ii) It was observed that super oxide radical played an important role in rat hepatic injury associated with ischemia and the injury was prevented by and administration of free radical scavenger (Alopurinol).iii) Severe hepatic failure in rats was induced by galactosamine and the level of ATP in the liver remarkably decreased, but the level was maintained within normal range by and administration of DBcAMP which was second messenger in the cell.

多器官功能衰竭（Multiple organ failure，MOF）是创伤后或手术后可发生的一种综合征。这种综合征是提高手术能力和患者护理的自然结果，但有时仍然是致命的。最近，它已经指出，该综合征的主要病理生理学是严重的败血症观察到的受伤或手术患者。这些患者通常是网状内皮细胞宿主防御机制受损，血清纤维连接蛋白水平低，而氧自由基的形成可能在某些组织损伤中起重要作用.因此，本研究旨在探讨MOF患者低纤连蛋白血症与超氧化物自由基之间的病理生理关系。临床患者血浆纤维连接蛋白的变化观察到严重脓毒症和肝功能衰竭患者血浆纤维连接蛋白水平明显下降。手术插入后水平也下降，但在正常过程中一周后再次上升。实验研究; i）腹腔感染大鼠血浆纤连蛋白水平下降，严重脓毒症动物死亡。ii）观察到超氧自由基在大鼠缺血性肝损伤中起重要作用，自由基清除剂可预防损伤（Alopurinol）.iii）半乳糖胺诱导大鼠严重肝衰竭，肝中ATP水平显著降低，但通过给予细胞内第二信使DBcAMP使其水平维持在正常范围内。