Bioactive glasses for the treatment of dentin hypersensitivity

用于治疗牙本质过敏的生物活性玻璃

• 批准号: 545171-2019
• 负责人: Nazhat, Showan
• 金额: $ 8.92万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Idea to Innovation
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=693341
• 关键词: Bioactive; glasses; treatment; dentin; hypersensitivity

Dentin Hypersensitivity ("tooth sensitivity") is a common clinical condition that results in sharp pain and affects about half the adult population. The main cause is due to enamel loss, either through to periodontal disease (e.g., gingivitis) or through diet (e.g., acidic foods and drinks), which exposes the underlying dentin layer and cannot be repaired by the body. Current treatment methods either mask the underlying problem through desensitizing the root nerves or require long treatment times to form a protected layer on the dentin surface.We have invented a novel platform technology, in the form of a bioactive glass, that can rapidly convert to bone-like mineral (e.g., enamel) at a rate of over 25 times faster than the current, commercially used bioactive glasses. This rapid conversion time will potentially translate into rapid hypersensitivity relief for the patient.In this project, we propose to advance this technology as a commercially viable product by examining the scalability of the processing as well as develop a prototype dental paste incorporating our bioactive glass for use in in-office treatment of sensitivity. We will work in collaboration with the Xerox Research Center of Canada with extensive expertise in bringing laboratory scale materials to a commercial scale. Additionally, we will develop and test the paste. Completion of these goals will create a product that can rapidly relieve tooth sensitivity.Our ultimate aim is to establish a Canadian start-up company as a bioactive glass manufacturer that will be used in a number of biomedical applications, including the dental field and will directly improve the quality of Canadian lives.

牙本质超敏反应（“牙齿敏感性”）是一种常见的临床状况，会导致剧烈的疼痛，并影响大约一半的成人人群。主要原因是由于牙釉质损失，要么是牙周疾病（例如牙龈炎）或饮食（例如酸性食品和饮料），该疾病暴露了基础牙本质层，因此无法通过人体修复。当前的治疗方法要么通过脱敏根神经来掩盖潜在的问题，要么需要长时间的治疗时间才能在牙本质表面形成受保护的层。我们已经以生物活性玻璃的形式发明了一种新型的平台技术，可以快速转化为骨状矿物（例如，enamel）以超过25倍的速度以超过25倍的速度，比当前使用的Bio commercerveassive commercerive commercive commercive commercive commercive commercive commercive commercive commercive玻璃杯。这个快速的转化时间将有潜在地转化为患者的快速过敏性缓解。在本项目中，我们建议通过检查加工的可伸缩性以及开发一种原型牙科粘贴，并结合我们的生物活性玻璃，以在敏感性中使用我们的生物活性玻璃，以推动这项技术作为商业上可行的产品。我们将与加拿大施乐研究中心合作，并拥有广泛的专业知识，以将实验室规模材料提升到商业规模。此外，我们将开发和测试糊状物。这些目标的完成将创造一种可以快速减轻牙齿敏感性的产品。我们的最终目标是建立一家加拿大初创公司作为生物活性玻璃制造商，该公司将用于许多生物医学应用，包括牙科领域，并将直接改善加拿大生活的质量。