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Studies on the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis

夏季型过敏性肺炎病原及发病机制的研究

基本信息

批准号：
62570349
负责人：
ANDO Masayuki
金额：
$ 1.34万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1988
项目状态：
已结题

项目摘要

We studied the etiologic agent and pathogenesis of summer-type hypersensitivity pneumonitis (HP). Our results were as follows.i. Studies on the etiologic agent of summer-type HP When the incidence of fungi in patients' homes were compared with that in homes of control subjects, extensive distribution of trichosporon cutaneum, an arthro-spore forming yeast, war observed in home environments of patients with summer-type HP but not in homes of normal control subjects. The isolated t. cutaneum demonstrated high reactivity to the patients' sera. almost all patients responded to the inhalation challenge with the culture filtrate antigen of t. cutaneum. These results clearly indicate that T. cutaneum is an etiologic agent of summer type HP. HP induced by T. cutaneum is a new disease of HP groups.ii. Studies on the pathogenesis of summer-type HP. Environmental study revealed that summer-type HP tended to occur in the resident of old wooded houses, and that T. cutaneum grew on old damp wood, floor mats, bed clothes, or budgeriger droppings in their houses during muggy summer season following the rainy season. In other words, summer-type HP in Japan is a sick-house syn-drome. The phenotype of the major histocompatibility complex, loci A, B, C, DR, and DQ, was studied in 66 patients with Japanese summer-type HP induced by T. cutaneum, and the results were compared to those obtained from 472 normal healthy subjects. Our results showed an increase of the frequency of HLA-DQW3 in the patients, suggesting the importance of the host factors for the generation of this disease.

对夏型过敏性肺炎(HP)的病因病机进行了研究。我们的研究结果如下。夏季幽门螺杆菌病原学的研究比较患者家庭和对照组家庭真菌的发生率，发现在夏季幽门螺杆菌患者家庭环境中广泛分布的形成节孢子的酵母菌--皮肤毛孢子菌，在正常对照组家庭环境中未见。分离的皮肤毛滴虫对患者血清具有较高的反应性。几乎所有的患者对吸入攻击都有皮肤结核杆菌培养滤液抗原的反应。这些结果表明，皮肤毛滴虫是夏季幽门螺杆菌的病原体。由皮肤毛滴虫引起的幽门螺杆菌是幽门螺杆菌群的一种新疾病。夏型幽门螺杆菌致病机制的研究。环境研究表明，夏季型幽门螺杆菌倾向于发生在老林木房屋的居民身上，在雨季过后闷热的夏季，皮肤毛滴虫在房子里的旧潮湿木头、地垫、床上用品或虎皮鹦鹉粪便上生长。换句话说，日本的夏季型惠普是一种病院综合症。对66例皮肤毛滴虫诱导的日本夏型幽门螺杆菌患者的主要组织相容性复合体A、B、C、DR和DQ的表型进行了研究，并与472例正常人的结果进行了比较。我们的结果显示，患者的HLADQW3基因频率增加，提示宿主因素在本病的发生中起着重要作用。