Study of pathogenic mechanism of summer-type hypersensitivity pneumonitis

夏季型过敏性肺炎发病机制研究

• 批准号: 06670621
• 负责人: ANDO Masayuki
• 金额: $ 1.41万
• 依托单位: KUMAMOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06670621/
• 关键词: Summer-type hypersensitivity pneumonitis; BAL; CD8+T cell; Chemokinesis; Chemokine; Adhesion molecule; Signal transduction; PKC; CD4T細胞; CD8T細胞; サイトカイン; BAL細胞

(1) Investigation of chemottactic substance and chemokine in BAL fluid in HP patientThe antigenic protein level of RANTES,which is chemoattractive for memory T cell, in BAL fluid of HP patient was significantly elevated as compared with other interstitial lung disease such as BOOP,sarcoidosis.(2) Investigation of expression of adhesion molecule on BAL T cellThe expression of adhesion molecule on BAL T cell of HP patient was significantly increased as compared with BAL T cells of BOOP and sarcoidosis.(3) Investigation of expression of protein kinase C isozyme in BAL T cellsThe expression of protein kinase C isozyme, which play an important roll in signal tansduction, was investigated. The expession pattern of PKC isozyme of BAL T cell was different from that of peripheral blood T cell.Fron these results, the mechanism of T cell recruitment into lung in HP and difference in signal transuduction in BAL T cell may become partially clear.

(1)Hp患者BAL液中趋化物质及趋化因子的研究Hp患者BAL液中对记忆T细胞具有趋化作用的RANTES抗原蛋白水平明显高于其他间质性肺疾病如BOOP、结节病等。(2)BAL T细胞表面黏附分子表达的研究HP患者BAL T细胞表面黏附分子的表达明显高于BOOP和结节病患者BAL T细胞。BAL T细胞与外周血T细胞PKC同工酶的表达模式不同，这一结果可能对幽门螺杆菌T细胞向肺内募集的机制及BAL T细胞信号转导的差异有了一定的了解。

项目成果

山崎寿人 他: "びまん性肺疾患におけるBALT細胞上の接着因子の発現の差-サルコイドーシスと過敏性肺炎BOOPの比較を中心に-" 厚生省特定疾患びまん性肺疾患調査研究班平成6年度研究報告書. 116-118 (1995)

Hisato Yamazaki等：《弥漫性肺病中BALT细胞上粘附因子表达的差异 - 重点关注结节病和过敏性肺炎 BOOP 之间的比较 -》 厚生省、厚生省特定疾病弥漫性肺病调查研究小组1994年研究报告.116-118 (1995)

山崎寿人 他: "びまん性肺疾患におけるBALT細胞上の接着因子の発現の差-サルコイドーシスと過敏性肺炎、BOOPの比較を中心に-" 厚生省特定疾患 びまん性肺疾患調査研究班 平成6年度研究報告書. 116-118 (1995)

Hisato Yamazaki等：“弥漫性肺疾病中BALT细胞上粘附因子表达的差异-以结节病、过敏性肺炎和BOOP的比较为重点-”厚生省特定疾病弥漫性肺疾病调查研究组1994年研究报告书。116-118（1995）

山崎寿人 他: "BAL中T細胞の表面抗原性および機能の特異性" 日本臨床. 52. 1462-1466 (1994)

Hisato Yamazaki 等人：“BAL 中 T 细胞的表面抗原性和功能特异性”日本临床杂志 52. 1462-1466 (1994)。

Yamasaki et al: "Specifity of surface antigen and function of BAL T lymphocyte" NIHON RINSHOU. 52. 1462-1466 (1994)

Yamasaki 等：“表面抗原的特异性和 BAL T 淋巴细胞的功能”NIHON RINSHOU。

Yamasaki et al: "Expression of adhesion molecules on BAL T lymphocyte of diffuse lung disease" Report of Kousei-sho Tokutei Shikkan, Bimansei Hai-Shikkan Kenkyu Group. 116-118 (1995)

Yamasaki等人：“弥漫性肺病BAL T淋巴细胞上粘附分子的表达”，美万世Hai-Shikkan Kenkyu小组Kousei-sho Tokutei Shikkan的报告。