Study of pathogenic mechanism of summer-type hypersensitivity pneumonitis

(1)HP患者支气管肺泡灌洗液中趋化物质和趋化因子的研究HP患者支气管肺泡灌洗液中对记忆T细胞具有趋化作用的RANTES抗原蛋白水平明显高于BOOP、结节病等间质性肺疾病。(2)BALT细胞表面粘附分子表达的研究HP患者BALT细胞表面粘附分子的表达明显高于BOOP和结节病患者。(3)蛋白激酶C同工酶在BAL T细胞中表达的研究蛋白激酶C同工酶在BAL T细胞中表达的研究BALT细胞PKC同工酶表达模式与外周血T细胞不同，这一结果可部分阐明HP时T细胞募集入肺的机制及BALT细胞信号转导的差异。

(1) Investigation of chemottactic substance and chemokine in BAL fluid in HP patientThe antigenic protein level of RANTES,which is chemoattractive for memory T cell, in BAL fluid of HP patient was significantly elevated as compared with other interstitial lung disease such as BOOP,sarcoidosis.(2) Investigation of expression of adhesion molecule on BAL T cellThe expression of adhesion molecule on BAL T cell of HP patient was significantly increased as compared with BAL T cells of BOOP and sarcoidosis.(3) Investigation of expression of protein kinase C isozyme in BAL T cellsThe expression of protein kinase C isozyme, which play an important roll in signal tansduction, was investigated. The expession pattern of PKC isozyme of BAL T cell was different from that of peripheral blood T cell.Fron these results, the mechanism of T cell recruitment into lung in HP and difference in signal transuduction in BAL T cell may become partially clear.