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Pathological and epidemiological studies on the pathogenesis of B-cell lymphoma

B细胞淋巴瘤发病机制的病理学和流行病学研究

基本信息

批准号：
01015065
负责人：
AOZASA Katsuyuki
金额：
$ 1.34万
依托单位：
Nara Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Cancer Research
财政年份：
1989
资助国家：
日本
起止时间：
1989 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01015065/
关键词：
Malignant lymphoma B-cell lymphoma Chronic inflammation Autoimmune disease tuberculosis

项目摘要

The purpose of this study is to show an etiologically important role of long-standing inflammation for development of B-cell lymphoma. The main results of my study obtained during the period April 1989 to January 1990 are as follows: 1. Thyroid lymphoma (1) Chromosome analysis suggested that thyroid lymphoma could be divided into two groups: the first group showed numerical abnormalities with clinical features of relatively slow growing struma and presence of anti-thyroid antibodies in the serum. The second group showed structural abnormalities such as 14q+ with rapidly growing struma and low positive rate of antithyroid antibodies. (2) Thyroid lymphomas in ATL non-endemic area were exclusively of B-cell type, but integration of EB virus genomes in the tumor cells were exceptional in these tumors. We are now making pathological and immunological studies on the patients with Hashimoto's disease and thyroid lymphoma in the ATL endemic area. 2. Pleural lymphoma developing in the patients with chronic tuberculous pyothorax I had previously suggested an etiologically important role of chronic tuberculous pyothorax for development of pleural lymphoma. In 1989, we have carried out nation-wide study of pleural lymphoma in Japan, and the results were (1) the age of patients ranged from 46-81 years(mean 63 years) with a male to female ratio of 5.2:1, (2) all patients had over 20 years history of Chronic tuberculous pyothorax, (3) tumor cells were exclusively of B-cell type.From the findings shown by us and other investigators it is suggested that B-cell lymphoma could evolve in the tissue affected by chronic inflammation of autoimmune or non-autoimmune nature. I am now preparing case-control study to investigate risk factor for development of pleural lymphomas among the patients with tuberculous pyothoiax.

本研究的目的是显示长期炎症对B细胞淋巴瘤发展的重要病因作用。本研究于1989年4月至1990年1月进行，主要结果如下：1.甲状腺淋巴瘤（1）染色体分析提示，甲状腺淋巴瘤可分为两组：第一组染色体数目异常，临床表现为甲状腺肿生长相对缓慢，血清中有抗甲状腺抗体。第二组表现为结构异常，如14 q+，甲状腺肿迅速增长，抗甲状腺抗体阳性率低。(2)ATL非流行区的甲状腺淋巴瘤均为B细胞型，但EB病毒基因组在肿瘤细胞中的整合在这些肿瘤中是例外。我们正在对ATL流行区的桥本病和甲状腺淋巴瘤患者进行病理学和免疫学研究。2.胸膜淋巴瘤发生于慢性结核性脓胸患者，我以前曾提出慢性结核性脓胸在胸膜淋巴瘤的发生中具有重要的病因作用。1989年，我们在日本全国范围内对胸膜淋巴瘤进行了研究，结果表明：（1）患者年龄46-81岁（平均63岁），男女之比为5.2：1;（2）所有患者均有20年以上的慢性结核性脓胸病史;（3）肿瘤细胞均为B细胞型。我正在准备一项病例对照研究，以探讨结核性脓胸患者发生胸膜淋巴瘤的危险因素。