Pathological and epidemiological studies on the pathogenesis of B-cell lymphoma

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The purpose of this study is to show an etiologically important role of long-standing inflammation for development of B-cell lymphoma. The main results of my study obtained during the period April 1989 to January 1990 are as follows: 1. Thyroid lymphoma (1) Chromosome analysis suggested that thyroid lymphoma could be divided into two groups: the first group showed numerical abnormalities with clinical features of relatively slow growing struma and presence of anti-thyroid antibodies in the serum. The second group showed structural abnormalities such as 14q+ with rapidly growing struma and low positive rate of antithyroid antibodies. (2) Thyroid lymphomas in ATL non-endemic area were exclusively of B-cell type, but integration of EB virus genomes in the tumor cells were exceptional in these tumors. We are now making pathological and immunological studies on the patients with Hashimoto's disease and thyroid lymphoma in the ATL endemic area. 2. Pleural lymphoma developing in the patients with chronic tuberculous pyothorax I had previously suggested an etiologically important role of chronic tuberculous pyothorax for development of pleural lymphoma. In 1989, we have carried out nation-wide study of pleural lymphoma in Japan, and the results were (1) the age of patients ranged from 46-81 years(mean 63 years) with a male to female ratio of 5.2:1, (2) all patients had over 20 years history of Chronic tuberculous pyothorax, (3) tumor cells were exclusively of B-cell type.From the findings shown by us and other investigators it is suggested that B-cell lymphoma could evolve in the tissue affected by chronic inflammation of autoimmune or non-autoimmune nature. I am now preparing case-control study to investigate risk factor for development of pleural lymphomas among the patients with tuberculous pyothoiax.