Patho-epidemiological study on the nasal NK/T cell lymphoma.

1. PCR-SSCP法结合直接测序，揭示了日本、韩国和中国东北地区鼻部NK/ t细胞淋巴瘤（NKTCL）患者p53、c-kit、k-ras和β-catenin基因突变的频率和模式不同。这些发现表明，生活方式和遗传因素可能是nktcl的致病因素。随后对包括农药使用在内的生活方式和NKTCL发展的流行病学研究揭示了以下重要变量：农民4.15(CI:1.74 ~ 9.87)，作物生产者2.81(CI:1.49 ~ 5.29)，农药使用者5.21(CI:1.30 ~ 20.86)，垃圾焚烧厂附近居民11.65（CI:1.17 ~ 115.82）。通过使用手套和眼镜并在使用农药时向下喷洒来减少农药暴露的作物生产者的相对风险较低，分别为0.11(CI:0.02-0.70), 0.18（CI;0.01-2.26）和0.11（CI:0.02-0.66）。这些发现表明，接触杀虫剂和化学溶剂可能是NKTCL的病因。

1. PCR-SSCP method followed with direct sequencing revealed the different frequency and pattern of p53, c-kit, k-ras, and β-catenin gene mutations in cases with nasal NK/T-cell lymphoma (NKTCL) between Japan, Korea, and northeast district of China. These findings suggest that life-style and genetical factors might be causative factors for NKTCL.2. Subsequent epidemiological study on the life-style including pesticide use and NKTCL development revealed the important variables as follows : 4.15(CI:1.74-9.87) for farmers, 2.81(CI:1.49-5.29) for producers of crops, 5.21(CI:1.30-20.86) for pesticide users, 11.65(CI:1.17-115.82) for residents near garbage burning plants. Relative risk was lower in crop producers who minimized their exposure to pesticides by using gloves and glasses and sprinkling downward at the time of pesticide use, 0.11(CI:0.02-0.70), 0.18(CI;0.01-2.26), and 0.11(CI:0.02-0.66), respectively, than those who did not. These findings suggest the exposure to pesticides and chemical solvents could be causative of NKTCL.