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Study on patho-epidemiology of malignant lymphoma in Japan

日本恶性淋巴瘤病理流行病学研究

基本信息

批准号：
16390105
负责人：
AOZASA Katsuyuki
金额：
$ 6.85万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390105/
关键词：
malignant lymphoma etiology EB virus rheumatoid arthritis prognosis 病理疫学ウィルス遺伝子変異予後

项目摘要

The study based on the cases with malignant lymphomas registered in the Osaka Lymphoma Study Group and the cases with pyothorax-associated lymphoma (PAL) and nasal NK/T-cell lymphoma (NKTCL). Malignant lymphomas developed in rheumatoid arthritis were also included. Epidemiological and molecular analysis were performed on these cases. The main findings obtained from these findings were as follows.1. Case-control study in Japan(5 institutes), Korea (Yonsei Univ), and China (China Medical Univ) revealed that pesticides and chemical solvents were risk factors for development of NKTCL (Int J Cancer 2006).2. PAL is an EBV-associated lymphoma. Loss of EBNA-2 one of EBV-coded latent genes, correlated with prognosis of PAL patients (Int J Cancer 2006).3. It is known that lymphoproliferative disease (LPD) develop relative frequently in patients with rheumatoid arthritis (RA), in which methotrexate (MTX) administration for RA is supposed to be involved. Then we compared the RA-LPD with and without MT X medication, showing no fundamental differences between them. (J Rheum 2007).4.Mutations of DNA mismatch repair genes, ATM, ATR, and MRE 11, in 50 cell lines from lymphoid leukemias and lymphomas, were examined. Mutations of ATM and MRE 11 were occasionally found. These mutations might cause genome instability, and finally result in lymphoid neoplasias. (Cancer Sci 2006).

该研究基于大坂淋巴瘤研究组登记的恶性淋巴瘤病例以及脓胸相关淋巴瘤（PAL）和鼻NK/T细胞淋巴瘤（NKTCL）病例。类风湿性关节炎中发生的恶性淋巴瘤也包括在内。对这些病例进行流行病学和分子生物学分析。主要研究结果如下：1.日本（5个研究所）、韩国（延世大学）和中国（中国医科大学）的病例对照研究显示，农药和化学溶剂是NKTCL发生的危险因素（Int J Cancer 2006）. PAL是一种EBV相关淋巴瘤。EBNA-2是EBV编码的潜伏基因之一，与PAL患者的预后相关（Int J Cancer 2006）。淋巴组织增生性疾病（LPD）是类风湿性关节炎（RA）患者的常见疾病，甲氨蝶呤（MTX）治疗RA可能与LPD有关。然后，我们比较了有和没有MT X药物的RA-LPD，显示它们之间没有根本差异。（J Rheum 2007）。4.检测了来自淋巴性白血病和淋巴瘤的50个细胞系中DNA错配修复基因ATM、ATR和MRE 11的突变。ATM和MRE 11的突变也时有发生，这些突变可能导致基因组的不稳定，最终导致淋巴瘤的发生。（Cancer Sci 2006）。