The first generation of single entity measurement tools for analysis

第一代用于分析的单一实体测量工具

• 批准号: FL150100060
• 负责人: Prof John Gooding
• 金额: $ 202.86万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Australian Laureate Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-10-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FL150100060
• 关键词: first; generation; single; entity; measurement

The first generation of single entity measurement tools for analysis: This fellowship project aims to develop a new type of diagnostic device that measures single molecules or single cells. Such measurements seek to revolutionise analysis by allowing heterogeneity and rare events in samples to be identified, rather than the average information provided by existing tools. With single molecule devices, the heterogeneity in response enables the development of multiplexed, calibration free sensors. The outcomes of the project are hoped to be completely new thinking on performing measurements, new knowledge regarding heterogeneity in biology and the potential for novel commercialised sensors. It is expected that this will be important not only in biological discovery, but also in providing far more robust sensors for applications such as environmental monitoring, disease prediction, personalised medicine or drug discovery.

第一代用于分析的单一实体测量工具：该奖学金项目旨在开发一种测量单分子或单细胞的新型诊断设备。这种测量试图通过允许识别样本中的异质性和罕见事件来彻底改变分析，而不是现有工具提供的平均信息。对于单分子装置，响应的异质性使得能够开发多路复用的免校准传感器。该项目的成果有望成为进行测量的全新思维，关于生物学异质性的新知识以及新型商业化传感器的潜力。预计这不仅在生物发现方面很重要，而且在为环境监测、疾病预测、个性化医疗或药物发现等应用提供更强大的传感器方面也很重要。