Bioinks that Advance 3D bioprinting of cells to the 4th dimension

将细胞 3D 生物打印推进到第四维的生物墨水

• 批准号: LP210200868
• 负责人: Prof John Gooding
• 金额: $ 35.98万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP210200868
• 关键词: Bioinks; Advance; 3D; bioprinting; cells

The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vivo events never previously possible with more realistic models of what is found in vivo. Applications are in fundamental cell biology, studying diseases and developing new drugs. The outcomes from this research will be new knowledge on designing cheap extracellular matrix mimics and high throughout 3D cell assays.

这项研究的目的是提供一种简单的方法，用于使用3D打印创建复杂的3D细胞培养物，用于体外细胞检测。一种通用的聚合物系统作为由完全市售的组件制成的生物墨水，将被推进，提供全方位的软组织模拟物，并且可以在3D细胞培养物打印后按需动态改变。后者将提供体内事件的体外模拟，这在以前是不可能的，更现实的模型是在体内发现的。应用于基础细胞生物学，研究疾病和开发新药。这项研究的结果将是设计廉价的细胞外基质模拟物和高通量3D细胞测定的新知识。