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A gold-coated magnetic nanoparticle biosensor for detecting microRNA

A gold-coated magnetic nanoparticle biosensor for detecting microRNA
一种用于检测 microRNA 的金涂层磁性纳米粒子生物传感器
批准号：
LP150101014
负责人：
Prof John Gooding
金额：
$28.52万
依托单位：
The University of New South Wales
依托单位国家：
澳大利亚
项目类别：
Linkage Projects
财政年份：
2016
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2016-11-01 至 2020-05-31
来源：
https://dataportal.arc.gov.au/RGS/Web/Grants/LP150101014
关键词：
goldcoatedmagneticnanoparticlebiosensor

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英文摘要
The project aims to develop a biosensor for detecting short sequences of RNA, called microRNA (miRNA) in blood. There are about 100 miRNA sequences that are involved in most biological processes. Changes in the levels of some miRNA sequences can serve as a biomarker for many diseases including cancers. The miRNA will be detected using gold-coated magnetic nanoparticles modified with DNA sequences complementary to the miRNA of interest to capture the miRNA. Application of a magnetic field allows the levels of miRNA to be detected electrochemically. The expected outcome is a commercialisable biosensor for miRNA both as a diagnostic early detection device and a prognostic device for a range of miRNA biomarkers.
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