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Studies on the Role of A Novel Ca^<2+>-Binding Protein Regucalcin in Liver Cell Functions

Studies on the Role of A Novel Ca^<2+>-Binding Protein Regucalcin in Liver Cell Functions
新型Ca^2结合蛋白Reguccalcin对肝细胞功能作用的研究
批准号:
63571053
负责人:
YAMAGUCHI Masayoshi
金额:
$1.15万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for General Scientific Research (C)
财政年份:
1988
资助国家:
日本
项目状态:
已结题
起止时间:
1988 至 1989

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中文摘要
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英文摘要
1) ^<125>I-Regucalcin binds to isolated liver plasma membranes, and activated (Ca^<2+>-Mg^<2+>)-adenosine triphosphatase which functions as Ca^<2+> PUMP.2) Ca^<2+> increased glucose-6-phosphatase activity in rat liver microsomes. The Ca^<2+> effect was reversed by regucalcin. Such effect was not seen in other metals.3) Regucalcin activated Ca^<2+>-adenosine triphosphatase in rat liver microsomes. This suggested the possibility that regucalcin regulates Ca^<2+> transport system.4) Regucalcin stimulated Ca^<2+> release from rat liver microsomes.5) Regucalcin inhibited protein kinase C activity in rat liver cytosol.6) Regucalcin inhibited Ca^<2+>/calmodulin-dependent protein kinase activity in rat liver cytosol.From these findings, it has been demonstrated that a novel Ca^<2+>-binding protein regucalcin regulates liver cell functions related to Ca^<2+>.
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会议论文
Masayoshi Ymaguchi: "Calcium-binding protein regucalcin is an activator of(Ca-Mg)-adenosine triphosphatase in the plasma membranes of rat liver" Chemical and Pharmaceutical Bulletin. 36. 3532-3539 (1988)
Masayoshi Ymaguchi:“钙结合蛋白 regucalcin 是大鼠肝脏质膜中 (Ca-Mg)-腺苷三磷酸酶的激活剂”《化学与制药通报》。
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通讯作者:
Masayoshi Yamaguchi,Seiichi Mori,Shinji Kato: "Calcium-binding protein regucalcin is an activator of(Ca-Mg)-adenosine triphosphatase in the plasma membranes of rat liver" Chemical and Pharmaceutical Bulletin. 36. 3532-3539 (1988)
Masayoshi Yamaguchi、Seiichi Mori、Shinji Kato:“钙结合蛋白 regucalcin 是大鼠肝脏质膜中 (Ca-Mg)-腺苷三磷酸酶的激活剂”《化学与药物通报》。
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Masayoshi Ymaguchi: "Inhibitory effect of calcium-binding protein regucalcin onprotein kinace C activity in rat liver cytosol" Biochemical Medicine and Metabolic Biology. (1990)
Masayoshi Ymaguchi:“钙结合蛋白调节钙蛋白对大鼠肝细胞质中蛋白激酶 C 活性的抑制作用”生化医学和代谢生物学。
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通讯作者:
Masayoshi Yamaguchi,Seiichi Mori: "Activation of hepatic microsomal Ca^<2+>-adenosine triphosphatase by calcium-binding protein regucalcin" Chemical and Pharmaceutical Bulletin. 37. 1031-1034 (1989)
Masayoshi Yamaguchi,Seiichi Mori:“钙结合蛋白调节钙素对肝微粒体Ca^2-腺苷三磷酸酶的激活”化学和药物通报。
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15
    Studies on Functional Regulation in Endogenous Regucalcin, An Intracellular Calcium Signaling Regulatory Protein, in Regucalcin Transgenic Rats
    • 批准号:
      13672292
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      YAMAGUCHI Masayoshi
    • 依托单位:
    Transcriptional Regulatory Mechanism for Ca^<2+>-Signaling Regulatory Protein Regucalcin Gene Which Is Expressed Specifically in Liver Cells
    • 批准号:
      10672048
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.11万
    • 财政年份:
      1998
    • 负责人:
      YAMAGUCHI Masayoshi
    • 依托单位:
    Gene Expression of Regulatory Protein Regucalcin of Ca^<2+>-Signaling and Its Regulatory Mechanism.
    • 批准号:
      08672522
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.47万
    • 财政年份:
      1996
    • 负责人:
      YAMAGUCHI Masayoshi
    • 依托单位:
    Expression of a novel Ca^<2+>-binding protein regucalcin and rlation to its physiologic role
    • 批准号:
      06672193
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $1.54万
    • 财政年份:
      1994
    • 负责人:
      YAMAGUCHI Masayoshi
    • 依托单位:
    海外基金