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Theoretical Study of Underlying Mechanism of Tremor with Reference to Its External Control

参考震颤外控机制的理论研究

基本信息

批准号：
63571075
负责人：
WATANABE Akira
金额：
$ 1.28万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63571075/
关键词：
Physiological tremor Biological modeling Stretch reflex Biomechanics モデル

项目摘要

The purpose of this study is to provide the means of analyzing tremor quantitatively with reference to its external control. Although tremor is expected to provide much neurological information, its underlying mechanism has not been clarified from the control-theoretical point of view so far. Previously, we proposed the two-reflex-loop model incorporating the spinal and supraspinal reflexes. In this study, attempts are made to validate the model experimentally and to develop the methodology of estimating the effect of external tremor control based on the model.Forced oscillation experiments are performed to validate the model. The wrist is fixed to a vibrator and hand acceleration and demodulated EMG are measured and analyzed by the FFT method. A systematic change in the phase angle between acceleration and demodulated EMG signals is observed. Results of simulation based on the model agree with the experimental results.In designing external tremor control by mechanical loading or external feedback, information is required of the tendency of oscillation. For the complex variable s=alpha+jomega in Laplace-transformed equations, the real part alpha can become positive or negative, corresponding to self-induced or damped oscillation, respectively. Hence alpha is considered to represent the tendency of oscillation. The effectiveness of this method is demonstrated by calculating the variables as functions of the two reflex loop gains.

本研究的目的是提供参考震颤的外部控制定量分析震颤的手段。虽然震颤有望提供许多神经学信息，但从控制理论的角度来看，迄今为止尚未阐明其潜在机制。以前，我们提出了两个反射环模型，将脊髓和脊髓上反射。在这项研究中，试图通过实验来验证该模型，并开发基于该模型的估计外部震颤控制效果的方法，强迫振荡实验进行验证模型。将手腕固定在振动器上，通过FFT方法测量和分析手部加速度和解调的肌电信号。观察到加速度和解调的EMG信号之间的相位角的系统变化。基于该模型的仿真结果与实验结果相吻合，在设计机械加载或外部反馈的外部震颤控制时，需要了解振动的趋势。在拉普拉斯变换后的方程中，对于复变量s=alpha+jomega，其真实的部分alpha可以变为正值或负值，分别对应于自激振荡和阻尼振荡。因此，α被认为代表振荡的趋势。通过计算作为两个反射回路增益的函数的变量，证明了该方法的有效性。